| Type | Description |
|---|---|
| Definition | Peptidoglycan recognition protein LE |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 10:25:00 | These results indicate that the absence of functional PGRP-LE alters the transcriptional pathway activity of Imd and Jnk signaling upon infection with Photorhabdus asymbiotica, while infection with Photorhabdus luminescens modifies the activity of Jak/Stat signaling. These findings denote the participation of the PGRP-LE receptor in the response of Drosophila melanogaster to Photorhabdus challenge. | 31404632 |
| 2017-11-11 12:33:00 | Protofibrils of peptidoglycan receptors PGRP-LC and PGRP-LE seed immune deficiency protein (Imd) amyloid polymerization via Imd RIP homotypic interaction motif (RHIM), and the formation of functional Imd amyloid fibril is required for NF-kappaB signaling. | 29045898 |
| 2013-01-26 11:44:00 | PGRP-LE functions as a gut bacterial sensor that induces balanced responses to infectious bacteria and tolerance to microbiota. | 22901536 |
| 2012-10-20 10:20:00 | our study delineates how a combination of extracellular sensing by PGRP-LC isoforms and intracellular sensing through PGRP-LE provides sophisticated mechanisms to detect and differentiate between infections in Drosophila. | 22772451 |
| 2010-06-28 11:49:00 | PGRP-LE and PGRP-LC play a crucial role in detecting extracellular and intracellular bacteria with DAP-type peptidoglycans to induce various innate immune responses | 20089584 |
| Type | IDs |
|---|---|
| Synonymous | CG8995, Dmel\CG8995, PGRP, anon-WO0153538.66, pgrp le, pgrp-le |
| Gene |
UniProtKB-ID:
PGPLE_DROME,
M9NDY2_DROME
UniprotKB:
Q9VXN9,
M9NDY2
UniParc:
UPI000007D129
EMBL:
AF313391,
AY058258,
AE014298
EnsemblGenome:
FBgn0030695
KO:
dme:Dmel_CG8995
|
| Nucleutide sequences |
EMBL-CDS:
AAG32064.1,
AAF48519.1,
AAL13487.1,
AFH07408.1
Gene_ORFName:
CG8995,
Dmel_CG8995,
CG8995
EnsemblGenome_TRS:
FBtr0307978,
FBtr0074183,
FBtr0074183,
FBtr0307978
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0300347,
FBpp0073968,
FBpp0300347,
FBpp0073968
RefSeq:
NP_001245695.1,
NP_573078.1
|
| Others |
UniRef100:
UniRef100_Q9VXN9
UniRef90:
UniRef90_Q9VXN9
UniRef50:
UniRef50_Q9VXN9
UniGene:
Dm.3371
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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