| Type | Description |
|---|---|
| Definition | TAR DNA binding protein |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 11:59:00 | tardbp hom/hom mutants displayed gross morphological defects, early lethality, reduced locomotor function, aberrant quantal transmission, and perturbed synapse architecture at the NMJ. tardbp(+/-); tardbpl(-/-), but not hom/hom mutants, were sensitive to chronic treatments of BAY K 8644, an L-type calcium channel agonist. This result highlights the importance of partial vs. complete loss of allelic functions of TDP-43. | 30461368 |
| 2016-08-06 11:45:00 | Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein tardbp and RNA binding protein fus. | 26930076 |
| 2013-05-25 11:32:00 | Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. | 23457265 |
| 2011-12-10 10:51:00 | TARDBP and FUS act in a pathogenic pathway that is independent of SOD1. | 21829392 |
| Type | IDs |
|---|---|
| Synonymous | wu:fb77f02, wu:fc52g10 |
| Gene |
UniProtKB-ID:
Q802C7_DANRE
UniprotKB:
Q802C7
UniParc:
UPI0000171B98
EMBL:
BX663614,
BC049348
Ensembl:
ENSDARG00000040031
KO:
dre:325052
|
| Nucleutide sequences |
EMBL-CDS:
AAH49348.1
Ensembl_TRS:
ENSDART00000058555
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000058554
RefSeq:
NP_958884.1
|
| Others |
UniRef100:
UniRef100_Q802C7
UniRef90:
UniRef90_Q802C7
UniRef50:
UniRef50_Q13148
UniGene:
Dr.2409
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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