| Type | Description |
|---|---|
| Definition | hepsin |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 13:20:00 | Our results demonstrate that a precise control of Hepsin proteolytic activity is critical for PCa cell fate and suggest, that the interference with ERAD could be a promising therapeutic option, leading to induction of proteotoxicity in hepsin-overexpressing tumors. | 31399560 |
| 2020-03-21 10:52:00 | Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells. | 31395734 |
| 2019-10-05 11:52:00 | Data indicate a critical cathepsin D (CtsD)-hepsin signaling in migration and metastasis, which may contribute to understanding of the function and molecular mechanism in breast cancer progression. | 30227221 |
| 2018-06-16 11:23:00 | Study showed was that Hepsin was downregulated in 78% of gastric cancer. Its high expression seems to predict poor prognosis. These results predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer. | 27841306 |
| 2018-06-09 10:04:00 | Genetic variation in/near the gene encoding for hepsin protein may influence risk of bipolar disorder and (at least for the rs62122114-A allele) may have functional impact (i.e. differential expression) as evidenced by serum HPN protein expression. | 28886448 |
| Type | IDs |
|---|---|
| Synonymous | TMPRSS1 |
| Gene |
UniProtKB-ID:
HEPS_HUMAN,
A0A140VJK9_HUMAN,
B7Z1L4_HUMAN
UniprotKB:
P05981,
A0A140VJK9,
B7Z1L4
UniParc:
UPI000003FE67,
UPI0001914AB3
EMBL:
BC025716,
X07732,
AK293622,
M18930,
AK315655,
HM005398,
X07002
Ensembl:
ENSG00000105707
KO:
hsa:3249
|
| Nucleutide sequences |
EMBL-CDS:
AAH25716.1,
CAA30558.1,
CAA30058.1,
AAA36013.1,
BAG38021.1,
AEE60996.1,
BAH11550.1
Ensembl_TRS:
ENST00000392226,
ENST00000673426,
ENST00000672452,
ENST00000262626
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000500909,
ENSP00000262626,
ENSP00000376060,
ENSP00000500664
RefSeq:
NP_002142.1,
XP_016882220.1,
XP_016882221.1,
NP_001371062.1,
NP_001362370.1,
NP_892028.1
|
| Others |
UniRef100:
UniRef100_B7Z1L4,
UniRef100_P05981
UniRef90:
UniRef90_B7Z1L4,
UniRef90_P05981
UniRef50:
UniRef50_P05981,
UniRef50_E2RKP5
UniGene:
Hs.182385
CCDS:
CCDS32993.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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