| Type | Description |
|---|---|
| Definition | hexosaminidase B (beta polypeptide) |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:26:00 | Hexb deficient zebrafish (hexb(-/-) ) showed lysosomal abnormalities already early in development both in radial glia, which are the neuronal and glial progenitors, and in microglia. Additionally, at 5 days postfertilization, hexb(-/-) zebrafish showed reduced locomotor activity. Although specific oligosaccharides accumulate in the adult brain, hexb(-/-) ) zebrafish are viable and apparently resistant to Hexb deficiency. | 31140649 |
| Type | IDs |
|---|---|
| Synonymous | fc04h11, hexa, si:dkey-35i22.2, wu:fc04h11, wu:fv09f06 |
| Gene |
UniProtKB-ID:
F1QUU0_DANRE,
A2BHD8_DANRE
UniprotKB:
F1QUU0,
A2BHD8
UniParc:
UPI0000545DFC,
UPI0001E91F95
EMBL:
FP016255,
BX571730
Ensembl:
ENSDARG00000034368
KO:
dre:323613
|
| Nucleutide sequences |
EMBL-CDS:
CAM16012.1
Gene_ORFName:
DKEY-35I22.2-001
Ensembl_TRS:
ENSDART00000097975,
ENSDART00000050271
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000088748,
ENSDARP00000050270
RefSeq:
NP_001108317.1,
XP_009299723.1,
XP_005171848.1,
NP_001296792.1,
XP_009299722.1
|
| Others |
UniRef100:
UniRef100_A2BHD8,
UniRef100_F1QUU0
UniRef90:
UniRef90_A3KNW3,
UniRef90_A2BHD8
UniRef50:
UniRef50_U3K4M4,
UniRef50_P07686
UniGene:
Dr.5384
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31508850 |
Gene expression profiling reveals a conserved microglia signature in larval zebrafish. Glia Julie Mazzolini , Sigrid Le Clerc , Gregoire Morisse , Cédric Coulonges , Laura E Kuil , Tjakko J van Ham , Jean-François Zagury , Dirk Sieger |
2020-02-01 | - |
| 31140649 |
Glia Laura E Kuil , Anna López Martà , Ana Carreras Mascaro , Jeroen C van den Bosch , Paul van den Berg , Herma C van der Linde , Kees Schoonderwoerd , George J G Ruijter , Tjakko J van Ham |
2019-09-01 | - |
| 30399334 |
Dev. Cell Ana M Meireles , Kimberle Shen , Lida Zoupi , Harini Iyer , Ellen L Bouchard , Anna Williams , William S Talbot |
2018-11-05 | - |
| 28252024 |
Evolution of complexity in the zebrafish synapse proteome. Nat Commun Ãlex Bayés , Mark O Collins , Rita Reig-Viader , Gemma Gou , David Goulding , Abril Izquierdo , Jyoti S Choudhary , Richard D Emes , Seth G N Grant |
2017-03-02 | - |
| 26774477 |
The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. Cell Rep Kimberle Shen , Harwin Sidik , William S Talbot |
2016-01-26 | - |
| 26469318 |
RFX transcription factors are essential for hearing in mice. Nat Commun Ran Elkon , Beatrice Milon , Laura Morrison , Manan Shah , Sarath Vijayakumar , Manoj Racherla , Carmen C Leitch , Lorna Silipino , Shadan Hadi , Michèle Weiss-Gayet , Emmanuèle Barras , Christoph D Schmid , Aouatef Ait-Lounis , Ashley Barnes , Yang Song , David J Eisenman , Efrat Eliyahu , Gregory I Frolenkov , Scott E Strome , Bénédicte Durand , Norann A Zaghloul , Sherri M Jones , Walter Reith , Ronna Hertzano |
2015-10-15 | - |
| 19389629 |
Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Chem Biol Mattias Kalén , Elisabet Wallgard , Noomi Asker , Aidas Nasevicius , Elisabet Athley , Erik Billgren , Jon D Larson , Shannon A Wadman , Elizabeth Norseng , Karl J Clark , Liqun He , Linda Karlsson-Lindahl , Ann-Katrin Häger , Holger Weber , Hellmut Augustin , Tore Samuelsson , Chelsy K Kemmet , Carly M Utesch , Jeffrey J Essner , Perry B Hackett , Mats Hellström |
2009-04-24 | - |
| 16109975 |
The zebrafish gene map defines ancestral vertebrate chromosomes. Genome Res. Ian G Woods , Catherine Wilson , Brian Friedlander , Patricia Chang , Daengnoy K Reyes , Rebecca Nix , Peter D Kelly , Felicia Chu , John H Postlethwait , William S Talbot |
2005-09-01 |
fgfr4,
pik3r3b,
trpv6,
poldip2,
dnase2,
rtf1,
ube2g1b,
ppp1r14bb,
pvalb3,
znf207b,
olig1,
sufu,
msi2a,
ppp4ca,
ppp1cb,
socs9,
nhp2,
kat8,
laptm4a,
fsta,
mthfd2,
mob1a,
dyrk1aa,
greb1l,
fn1a,
aldh9a1a.1,
cpt2,
sh3gl1a,
vps18,
arrdc1a,
sv2bb,
idh1,
sb:cb37,
tle3b,
erbb4a,
ap1g2,
parp2,
hbl3,
dhx37,
pcsk7,
rmdn3,
gtf3ab,
kif3b,
npl,
sall1b,
pard6ga,
arfgef1,
gdf5,
cog1,
casr,
slc25a28,
urb1,
ndufv3,
trip11,
casq2,
mpz,
rps9,
vars,
spry4,
ube2ia,
dlg1,
sim2,
blzf1,
copb2,
sec22ba,
tnfsf10l,
ednraa,
pklr,
vcana,
ywhag1,
jag1a,
jag2b,
jag1b,
vim,
tfap2a,
prps1a,
atic,
cyp1a,
ckbb,
psap,
gbx1,
ptk2ab,
meis1b,
mkrn2,
rbp5,
crabp2a,
ccna2,
hdac1,
csnk1a1,
mak16,
actl6a,
dtl,
stil,
pole2,
slc25a5,
cct7,
cct3,
smc4,
kif11
|
| 12618376 |
Genome Res. Jane Lo , Sorcheng Lee , Min Xu , Feng Liu , Hua Ruan , Alvin Eun , Yawen He , Weiping Ma , Weefuen Wang , Zilong Wen , Jinrong Peng |
2003-03-01 |
slc12a8,
sema5bb,
tmprss3a,
si:dkey-22o12.2,
rab32b,
si:ch211-166a6.5,
mettl24,
rragcb,
gpn3,
abl1,
glula,
map6a,
si:dkey-11p10.10,
eml6,
golim4a,
htr2cl1,
si:ch211-241d21.5,
iars2,
znf207b,
si:dkeyp-69e1.8,
fbxo30a,
rab22a,
calb1,
fam160a2,
ponzr10,
mtg2,
hectd1,
slc1a5,
rasa1a,
olfml2a,
lmod1a,
lenep,
pimr168,
si:dkey-49o11.1,
LOC100002756,
nkain4,
cdc42ep4b,
si:dkey-105e17.1,
tmem150c,
tcirg1a,
ppp1cb,
lrch4,
abhd17ab,
plekhb2,
aknad1,
colgalt2,
pmch,
anks1ab,
si:ch211-204d2.4,
si:ch211-226m16.2,
sgpp1,
trim2a,
znf516,
zeb2a,
zgc:112265,
p2ry1,
adamts12,
si:ch211-198n5.11,
med13a,
ddb2,
tbx5b,
cd28,
kcnt1,
si:dkey-61l1.4,
cep350,
tmc8,
slc35a1,
atp6ap1a,
fsd1l,
cyp24a1,
si:ch211-243a15.1,
c1ql2,
ar,
dnmbp,
calhm1,
mybl2a,
ice2,
dnal4b,
slc5a7a,
cpo,
grin1b,
cgnb,
ehmt1a,
tuft1b,
arrdc1a,
znf687b,
sobpb,
si:dkey-266f7.5,
itga7,
si:dkeyp-53d3.6,
fktn,
whsc1l1,
senp7b,
alx4a,
slc2a5,
atf2,
si:ch73-177h5.3,
prkcba,
ankrd55
|
| 12477932 |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team |
2002-12-24 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员