| Type | Description |
|---|---|
| Definition | amyloid beta precursor protein binding family B member 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-29 11:10:00 | The findings reveal a novel mechanism whereby GSK3beta stimulates amyloidogenic processing of APP by phosphorylation of FE65 at threonine 579. | 28963516 |
| 2019-01-12 10:52:00 | FE65 is found to activate ELMO1 by diminishing ELMO1 intramolecular autoinhibitory interaction and to promote the targeting of ELMO1 to the plasma membrane, where Rac1 is activated. We also show that FE65, ELMO1, and DOCK180 form a tripartite complex | 29615491 |
| 2017-08-26 12:21:00 | Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 constructs expressed in human neuroblastoma cells. Our results indicate that PTB2 rather than the WW domain is important for the nuclear localization of Fe65. | 28323844 |
| 2017-07-15 11:40:00 | Fe65 Ser289 phosphorylation did not affect the transcriptional activity of the Fe65-APP complex, in contrast to the previously described Ser228 site. | 27176072 |
| 2017-06-03 10:10:00 | Our findings imply that APBB1 plays an important role in the maintenance of EMT-associated CSC-like properties and gamma-radiation resistance via activation of IGF1Rbeta/AKT/GSK3beta pathway in lung cancer cells, highlighting APBB1 as a potential target for therapeutic cancer treatment. | 27836546 |
| Type | IDs |
|---|---|
| Synonymous | FE65, MGC:9072, RIR |
| Gene |
UniProtKB-ID:
APBB1_HUMAN,
B7Z4M9_HUMAN
UniprotKB:
O00213,
B7Z4M9
UniParc:
UPI0001914C81,
UPI000258D162,
UPI0001914EFF,
UPI000012510B,
UPI0001914AA2,
UPI00005A8E5D,
UPI0000070BF7
EMBL:
BX538185,
AC068733,
EF103274,
AF047835,
AK295241,
AK293643,
CH471064,
AK293554,
L77864,
AF029234,
AK293550,
BC010854,
AK297550,
AC084337
Ensembl:
ENSG00000166313
KO:
hsa:322
|
| Nucleutide sequences |
EMBL-CDS:
BAH11532.1,
ABL07489.3,
CAD98057.1,
AAC79942.1,
AAH10854.1,
EAW68723.1,
BAH11531.1,
EAW68724.1,
BAH11554.1,
BAH12016.1,
AAB93631.1,
BAH12615.1
Ensembl_TRS:
ENST00000608704,
ENST00000609360,
ENST00000608655,
ENST00000609331,
ENST00000608645,
ENST00000299402,
ENST00000530885,
ENST00000311051,
ENST00000608394
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000477069,
ENSP00000476442,
ENSP00000311912,
ENSP00000476646,
ENSP00000433338,
ENSP00000477213,
ENSP00000476846,
ENSP00000299402,
ENSP00000476871
RefSeq:
NP_001244252.1,
NP_001244250.1,
NP_001244248.1,
NP_001244249.1,
NP_663722.1,
NP_001155.1,
NP_001244255.1,
NP_001244254.1
|
| Others |
UniRef100:
UniRef100_O00213,
UniRef100_B7Z4M9
UniRef90:
UniRef90_O00213,
UniRef90_B7Z4M9
UniRef50:
UniRef50_A0A3B5KZ92,
UniRef50_O00213
UniGene:
Hs.372840
CCDS:
CCDS66017.1,
CCDS66015.1,
CCDS66016.1,
CCDS66018.1,
CCDS58114.1,
CCDS31410.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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