| Type | Description |
|---|---|
| Definition | kelch-like ECH-associated protein 1a |
| Date | Results | Publications |
|---|---|---|
| 2017-12-23 11:19:00 | These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization. | 27021962 |
| 2010-01-21 00:00:00 | study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds | 19001094 |
| 2010-01-21 00:00:00 | mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function | 18057000 |
| Type | IDs |
|---|---|
| Synonymous | keap1, wu:fb36f11 |
| Gene |
UniProtKB-ID:
KEP1A_DANRE
UniprotKB:
Q1ECZ2
UniParc:
UPI0000437594
EMBL:
BC117613,
BX663525,
BX927124,
AB081315
Ensembl:
ENSDARG00000016132
KO:
dre:321837
|
| Nucleutide sequences |
EMBL-CDS:
AAI17614.1,
BAC10574.2
Ensembl_TRS:
ENSDART00000045763
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000045762
RefSeq:
NP_878284.2
|
| Others |
UniRef100:
UniRef100_Q1ECZ2
UniRef90:
UniRef90_Q1ECZ2
UniRef50:
UniRef50_Q1ECZ2
UniGene:
Dr.52260
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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