| Type | Description |
|---|---|
| Definition | homeobox B4 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:18:00 | HOXB4 promotes the malignant progression of ovarian cancer via DHDDS. | 32178630 |
| 2019-02-16 12:31:00 | our data confirms that CaP growth and chemo-/radioresistance in vivo is associated with over-expression of EpCAM, which serves both a functional biomarker and promising therapeutic target. | 30419846 |
| 2018-11-17 11:57:00 | Data suggests that an impaired capacity of eutopic and ectopic endometrial tissue to upregulate levels of HOXB4 during the proliferative phase may play a role in the pathogenesis of endometriosis and that further downregulation of HOXB4 may enhance ectopic implant invasiveness. | 28969513 |
| 2018-07-28 11:01:00 | Authors observed that induced expression of HOXB4 in the UW473 cell line significantly reduced in vitro cell proliferation and migration capability of UW473 cells with no effect on the in vivo tumorigenicity. | 29039487 |
| 2018-06-02 12:07:00 | Study revealed that HOXB4 was highly expressed in ovarian cancer cells. HOXB4 silencing enhanced the cytotoxic effect of Taxol and DDP by downregulating ABC transporters via inhibition of the PI3K/Akt signaling pathway. These results for the first time elucidated the critical roles and molecular basis of HOXB4 underlying drug resistance in ovarian cancer cells. | 29660518 |
| Type | IDs |
|---|---|
| Synonymous | HOX-2.6, HOX2, HOX2F |
| Gene |
UniProtKB-ID:
HXB4_HUMAN
UniprotKB:
P17483
UniParc:
UPI0000062329
EMBL:
AL137449,
BC049204,
AF307160,
AF287967,
X16174
Ensembl:
ENSG00000182742
KO:
hsa:3214
|
| Nucleutide sequences |
EMBL-CDS:
CAB70742.1,
AAH49204.1,
AAG45052.1,
AAG31554.1,
CAA34296.1
Ensembl_TRS:
ENST00000332503
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000328928
RefSeq:
NP_076920.1
|
| Others |
UniRef100:
UniRef100_P17483
UniRef90:
UniRef90_P10284
UniRef50:
UniRef50_P10284
UniGene:
Hs.664706
CCDS:
CCDS11529.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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