| Type | Description |
|---|---|
| Definition | regulatory factor X, 6 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:06:00 | Rfx6 operates upstream of Arx, Pax6 and Isl1 to trigger the differentiation of peptidergic enteroendocrine cells such as GIP-, GLP-1-, or CCK-secreting cells. On the contrary, Rfx6 represses Lmx1a and Tph1, two genes essential for serotonin biosynthesis. | 31668390 |
| 2019-06-08 10:09:00 | Rfx6 can directly bind to upstream of MiR-145, MiR-195, and possibly other non-protein-coding functional RNAs to control adult mouse pancreatic differentiation. Interestingly, our study revealed that Rfx6 played an important role in insulin translation by binding to the Eif2ak1, Upf1, and Eif5. | 30509498 |
| 2015-07-25 10:36:00 | Rfx6 loss in adult beta cells leads to glucose intolerance, impaired beta cell glucose sensing, and defective insulin secretion. | 25497096 |
| 2013-03-30 11:27:00 | Rfx6 increases GIP expression and content in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. | 23192339 |
| 2010-03-29 12:01:00 | studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans | 20148032 |
| Type | IDs |
|---|---|
| Synonymous | 4930572O07Rik, Rfxdc1 |
| Gene |
UniProtKB-ID:
RFX6_MOUSE
UniprotKB:
Q8C7R7
UniParc:
UPI00000E99A0,
UPI00000E9217,
UPI0000194315
EMBL:
BC132104,
AK049380,
AK029809,
AC153527,
BC132294
Ensembl:
ENSMUSG00000019900
KO:
mmu:320995
|
| Nucleutide sequences |
EMBL-CDS:
AAI32105.1,
BAC33722.1,
BAC26627.1,
AAI32295.1
Ensembl_TRS:
ENSMUST00000122922,
ENSMUST00000050455
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000057384,
ENSMUSP00000116057
RefSeq:
NP_796280.1,
NP_001152861.1
|
| Others |
UniRef100:
UniRef100_Q8C7R7
UniRef90:
UniRef90_Q8C7R7
UniRef50:
UniRef50_Q8HWS3
UniGene:
Mm.109190
CCDS:
CCDS48558.1,
CCDS23835.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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