| Type | Description |
|---|---|
| Definition | OCRL, inositol polyphosphate-5-phosphatase |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 11:23:00 | These studies substantiate the first mouse model of Lowe syndrome and give insights into the role of OCRL in cellular trafficking of multiligand receptors. These insights open new avenues for therapeutic interventions in Lowe syndrome and Dent disease. | 30590522 |
| 2017-06-03 12:15:00 | These results suggest that the functions of OCRL/INPP5B and proton-chloride exchange transporter 5 converge on shared mechanisms, the impairment of which has a dramatic effect on proximal tubule endocytosis | 27895154 |
| 2015-10-17 11:22:00 | OCRL mRNA and protein were downregulated in osteoarthritis knee cartilage. OCRL inhibits Rac1 activation in OA. | 25917196 |
| 2014-11-22 12:34:00 | Implications of OCRL and TRPV4 in primary cilia function may also shed light on mechanosensation in other organ systems. | 25143588 |
| 2013-02-02 11:57:00 | Bcl10 was required to locally deliver the vesicular OCRL phosphatase that regulates PI(4,5)P(2) and F-actin turnover, both crucial for the completion of phagosome closure. | 23153494 |
| Type | IDs |
|---|---|
| Synonymous | 9530014D17Rik, BB143339, OCRL1 |
| Gene |
UniProtKB-ID:
OCRL_MOUSE
UniprotKB:
Q6NVF0
UniParc:
UPI00000EA6B3,
UPI00001C643E
EMBL:
AK041963,
AL714010,
BC068146,
AK047906
Ensembl:
ENSMUSG00000001173
KO:
mmu:320634
|
| Nucleutide sequences |
EMBL-CDS:
AAH68146.1,
BAE20614.1,
BAC33188.1
Ensembl_TRS:
ENSMUST00000001202,
ENSMUST00000115020
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000001202,
ENSMUSP00000110672
RefSeq:
XP_036017877.1,
XP_036017876.1,
NP_796189.2,
XP_017174013.1,
XP_036017879.1,
XP_036017878.1,
XP_011249310.1
|
| Others |
UniRef100:
UniRef100_Q6NVF0
UniRef90:
UniRef90_Q6NVF0
UniRef50:
UniRef50_Q01968
UniGene:
Mm.210343
CCDS:
CCDS40957.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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