Type | Description |
---|---|
Definition | left-right determination factor 2 |
Date | Results | Publications |
---|---|---|
2020-11-21 13:13:00 | LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-beta1/Smad3 pathway. | 32745796 |
2019-10-19 11:39:00 | Endometrial receptivity is negatively regulated by LEFTY2. LEFTY2 inhibits the expression of key murine receptivity genes. LEFTY2 downregulates the expression of Orai1 and inhibits SOCE. LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells. Targeting LEFTY2 and Orai1 may represent a novel approach for treating unexplained infertility. | 29230527 |
2017-02-04 11:48:00 | LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. | 27606670 |
2016-12-17 11:18:00 | Results indicate that microRNA miR-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2). | 27072135 |
2015-04-25 10:07:00 | Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry. | 24704359 |
Type | IDs |
---|---|
Synonymous | 6030463A22Rik, Ebaf, Lefta, Leftb, lefty-2, lefty-B |
Gene |
UniProtKB-ID:
LFTY2_MOUSE
UniprotKB:
P57785
UniParc:
UPI00000EB335
EMBL:
AK031621,
BC066224
Ensembl:
ENSMUSG00000066652
KO:
mmu:320202
|
Nucleutide sequences |
EMBL-CDS:
BAC27483.1,
AAH66224.1
Ensembl_TRS:
ENSMUST00000085797
|
Protein sequencees |
Ensembl_PRO:
ENSMUSP00000082952
RefSeq:
NP_796073.1
|
Others |
UniRef100:
UniRef100_P57785
UniRef90:
UniRef90_P57785
UniRef50:
UniRef50_Q64280
UniGene:
Mm.87078
CCDS:
CCDS15575.1
|