| Type | Description |
|---|---|
| Definition | left-right determination factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:13:00 | LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-beta1/Smad3 pathway. | 32745796 |
| 2019-10-19 11:39:00 | Endometrial receptivity is negatively regulated by LEFTY2. LEFTY2 inhibits the expression of key murine receptivity genes. LEFTY2 downregulates the expression of Orai1 and inhibits SOCE. LEFTY2 and the Orai1 blockers 2-APB, MRS-1845, and YM-58483 inhibit COX2, BMP2, and WNT4 expression in endometrial cells. Targeting LEFTY2 and Orai1 may represent a novel approach for treating unexplained infertility. | 29230527 |
| 2017-02-04 11:48:00 | LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. | 27606670 |
| 2016-12-17 11:18:00 | Results indicate that microRNA miR-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2). | 27072135 |
| 2015-04-25 10:07:00 | Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry. | 24704359 |
| Type | IDs |
|---|---|
| Synonymous | 6030463A22Rik, Ebaf, Lefta, Leftb, lefty-2, lefty-B |
| Gene |
UniProtKB-ID:
LFTY2_MOUSE
UniprotKB:
P57785
UniParc:
UPI00000EB335
EMBL:
AK031621,
BC066224
Ensembl:
ENSMUSG00000066652
KO:
mmu:320202
|
| Nucleutide sequences |
EMBL-CDS:
BAC27483.1,
AAH66224.1
Ensembl_TRS:
ENSMUST00000085797
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000082952
RefSeq:
NP_796073.1
|
| Others |
UniRef100:
UniRef100_P57785
UniRef90:
UniRef90_P57785
UniRef50:
UniRef50_Q64280
UniGene:
Mm.87078
CCDS:
CCDS15575.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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