| Type | Description |
|---|---|
| Definition | acetyl-CoA carboxylase beta |
| Date | Results | Publications |
|---|---|---|
| 2019-05-11 11:43:00 | Results identified ACC2 amino acid mutations affecting specific inhibition of the isozyme by compound CD-017-0191. They form two clusters separated by 60-90 A: one located in the vicinity of the BC active site and the other one in the vicinity of the ACC1 phosphorylation sites in the central domain, suggesting a contribution of the interface of two ACC dimers in the polymer to the inhibitor binding site. | 29772612 |
| 2019-01-19 11:50:00 | Targeted analysis of DNA methylation array revealed the mesenchymal stem cells in infants born to obese mothers had hypermethylation in genes regulating Oxidation (PRKAG2, ACC2, CPT1A, SDHC) and corresponding lower mRNA content of these genes. Moreover, mesenchymal stem cells methylation was positively correlated with infant adiposity. | 29107296 |
| 2018-11-17 10:55:00 | ACC2 gene (ACACB) expression was decreased by 25% in HCC tissue compared to non-cancerous liver tissue. | 28290443 |
| 2018-04-21 10:40:00 | of ACCs decreased polyunsaturated fatty acid (PUFA) concentrations in liver due to reduced malonyl-CoA, which is required for elongation of essential fatty acids. | 28768177 |
| 2017-09-09 12:11:00 | PHD3 loss in cancer enables metabolic reliance on fatty acid oxidation via deactivation of ACC2. | 27635760 |
| Type | IDs |
|---|---|
| Synonymous | ACC2, ACCB, HACC275 |
| Gene |
UniProtKB-ID:
ACACB_HUMAN
UniprotKB:
O00763
UniParc:
UPI0001AE6AC9,
UPI0003EAEB83,
UPI0000DBEEFB
EMBL:
U34591,
DQ493870,
AY382667,
U89344,
AJ575431,
AJ575592,
AC007637
Ensembl:
ENSG00000076555
KO:
hsa:32
|
| Nucleutide sequences |
EMBL-CDS:
CAE01471.3,
AAB58382.1,
AAR37018.1,
AAC50571.1,
CAE01470.2,
ABF48723.1
Ensembl_TRS:
ENST00000377848,
ENST00000338432
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000341044,
ENSP00000367079
RefSeq:
XP_011536566.1,
XP_011536567.1,
XP_016874741.1,
XP_011536561.1,
XP_011536565.1,
XP_006719430.1,
NP_001084.3
|
| Others |
UniRef100:
UniRef100_O00763
UniRef90:
UniRef90_O00763
UniRef50:
UniRef50_O00763
UniGene:
Hs.234898
CCDS:
CCDS31898.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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