| Type | Description |
|---|---|
| Definition | isthmin 1, angiogenesis inhibitor |
| Date | Results | Publications |
|---|---|---|
| 2016-05-28 10:06:00 | ISM is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation as well as induction of apoptosis | 25952901 |
| 2016-03-05 11:08:00 | ISM1 transcripts are found in tissues as the anterior mesendoderm, paraxial and lateral plate mesoderm, MHB and trunk neural tube, as well as in the somites and dermomyotome. In the newborn and adult, ISM1 is prominently expressed in the lung and brain. | 24675886 |
| 2015-06-20 10:46:00 | Given that ISM1 has been reported to have anti-angiogenic properties, these observations suggest that ISM1 is a mediator of lymphocyte effector functions and may participate in both innate and acquired immune responses. | 24956034 |
| 2012-04-21 10:26:00 | results demonstrate that Isthmin is a novel endogenous angiogenesis inhibitor with functions likely in physiological as well as pathological angiogenesis. | 19874420 |
| Type | IDs |
|---|---|
| Synonymous | 5430433G21Rik, Ism |
| Gene |
UniProtKB-ID:
V9GXR4_MOUSE
UniprotKB:
V9GXR4
UniParc:
UPI00001E3177
EMBL:
AL928831
Ensembl:
ENSMUSG00000074766
KO:
mmu:319909
|
| Nucleutide sequences |
Ensembl_TRS:
ENSMUST00000184404
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000139280
RefSeq:
NP_001263418.1,
XP_036018185.1,
XP_036018186.1
|
| Others |
UniRef100:
UniRef100_V9GXR4
UniRef90:
UniRef90_A2ATD1
UniRef50:
UniRef50_Q5EGE1
UniGene:
Mm.41113
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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