| Type | Description |
|---|---|
| Definition | ring finger and CCCH-type zinc finger domains 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-12-30 10:51:00 | Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional T cells and specialization of Treg cells. | 29246441 |
| 2013-07-20 11:19:00 | Study demonstrates that the constitutive decay element folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin initiates degradation of TNF-alpha mRNA and limits TNF-alpha production in macrophages. | 23663784 |
| 2013-07-13 10:37:00 | Roquin-1 and Roquin-2 proteins redundantly repressed the mRNA of inducible costimulator (Icos) and identified the Ox40 costimulatory receptor as another shared mRNA target. | 23583643 |
| 2013-07-13 10:37:00 | RING-deficient Roquin-1 failed to localize to stress granules and allowed Roquin-2 to compensate in the repression of ICOS and Tfh cells. | 23583642 |
| 2007-08-02 12:00:00 | Characterization of the human RC3H2 ortholog and observation of conserved sequences in mouse. | 10938276 |
| Type | IDs |
|---|---|
| Synonymous | 2900024N03Rik, 9430019J22Rik, D930043C02Rik, Mnab, Rnf164 |
| Gene |
UniProtKB-ID:
RC3H2_MOUSE,
Q148V4_MOUSE,
A2AVP4_MOUSE,
Q148V5_MOUSE
UniprotKB:
P0C090,
Q148V4,
A2AVP4,
Q148V5
UniParc:
UPI0000DA6CEE,
UPI0000DA6CEF,
UPI00001E309E,
UPI00001C264E
EMBL:
AL929572,
BC117952,
BC117951,
AL953890
Ensembl:
ENSMUSG00000075376
KO:
mmu:319817
|
| Nucleutide sequences |
EMBL-CDS:
AAI17953.1,
AAI17952.1
Ensembl_TRS:
ENSMUST00000112936,
ENSMUST00000100143,
ENSMUST00000112934
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000097721,
ENSMUSP00000108558,
ENSMUSP00000108556
RefSeq:
NP_001094061.1,
NP_001277571.1,
XP_006498187.1
|
| Others |
UniRef100:
UniRef100_P0C090,
UniRef100_A2AVP4,
UniRef100_Q148V4,
UniRef100_Q148V5
UniRef90:
UniRef90_P0C090
UniRef50:
UniRef50_Q9HBD1-4
UniGene:
Mm.288785,
Mm.485302
CCDS:
CCDS38116.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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