| Type | Description |
|---|---|
| Definition | insulin-like growth factor 2 mRNA binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 11:04:00 | The hepatocyte-specific IMP2 deficiency promotes modest diet-induced fatty liver by impairing fatty acid oxidation through increased degradation of the IMP2 client mRNAs PPARalpha and CPT1A. | 31209109 |
| 2020-01-04 12:09:00 | Niche-dependent regulation of neurogenesis after adult HI injury via the RNA-binding protein 3 (RBM3)-IGF2 mRNA binding protein 2 (IMP2)-insulin-like growth factor 2 (IGF2) signaling pathway. | 31484925 |
| 2019-06-15 12:28:00 | Study generated a high-resolution, genome-wide map of chromatin architecture in pancreatic islets and used this map to annotate candidate target genes of islet enhancers. At the IGF2BP2 locus, type 2 diabetes risk alleles reduce islet chromatin accessibility and expression of target gene IGF2BP2 and that conditional knockout of IGF2BP2 homolog Imp2 in mouse islets impairs glucose-stimulated insulin secretion. | 31064983 |
| 2018-01-20 11:52:00 | The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. | 24755648 |
| 2017-09-09 14:20:00 | results reveal a highly distinctive axonal enrichment of IMP2, show that it interacts with a network of axon guidance-related mRNAs, and reveal that it is required for normal axon pathfinding during vertebrate development. | 27385015 |
| Type | IDs |
|---|---|
| Synonymous | C330012H03Rik, IMP-2, Imp2, Neilsen |
| Gene |
UniProtKB-ID:
IF2B2_MOUSE
UniprotKB:
Q5SF07
UniParc:
UPI0000D89834,
UPI000046E5D0
EMBL:
AK170531,
CT009567,
AY531659
Ensembl:
ENSMUSG00000033581
KO:
mmu:319765
|
| Nucleutide sequences |
EMBL-CDS:
BAE41861.1,
AAT01428.1
Ensembl_TRS:
ENSMUST00000100052
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000097629
RefSeq:
NP_898850.2
|
| Others |
UniRef100:
UniRef100_Q5SF07
UniRef90:
UniRef90_Q9Y6M1
UniRef50:
UniRef50_Q9Y6M1
UniGene:
Mm.489442
CCDS:
CCDS49797.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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