| Type | Description |
|---|---|
| Definition | dual specificity phosphatase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-18 10:05:00 | MKP-2 has the potential to play a major role in regulating RA due to a direct effect on neutrophil function, with the potential to effect macrophages, osteoclast formation and bone development. | 30713718 |
| 2019-12-28 12:12:00 | Dusp4 was found to be expressed in skeletal muscle and plays a role in the regulation of muscle cell differentiation. | 30758994 |
| 2019-12-28 11:49:00 | Transcriptome profiling reveals that MKP-2 regulates macrophage development showing candidate targets from monocyte-to-macrophage differentiation and macrophage proliferation. However, it is unclear whether effects upon ERK signalling are able to explain the effects of DUSP-4 deletion on macrophage function. | 31336892 |
| 2019-11-09 10:23:00 | compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion synergistically activated MAPK signaling and promoted cell proliferation. | 30475228 |
| 2019-04-06 12:12:00 | Signalling via ERK1/2 and tuning by its negative regulator DUSP4 are critical elements of the vasoactive intestinal peptide-directed circadian re-programming. | 30710088 |
| Type | IDs |
|---|---|
| Synonymous | 2700078F24Rik, AI844617, BB104621, E130306H24Rik, MKP2 |
| Gene |
UniProtKB-ID:
DUS4_MOUSE
UniprotKB:
Q8BFV3
UniParc:
UPI00000EBAA1
EMBL:
AK080964,
AK053746
Ensembl:
ENSMUSG00000031530
KO:
mmu:319520
|
| Nucleutide sequences |
EMBL-CDS:
BAC35504.1,
BAC38097.1
Ensembl_TRS:
ENSMUST00000033930
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033930
RefSeq:
NP_795907.1
|
| Others |
UniRef100:
UniRef100_Q8BFV3
UniRef90:
UniRef90_Q8BFV3
UniRef50:
UniRef50_Q13115
UniGene:
Mm.170276,
Mm.392187
CCDS:
CCDS22241.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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