| Type | Description |
|---|---|
| Definition | G protein-coupled receptor 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-02-16 10:13:00 | Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4. | 29894771 |
| 2018-12-22 12:17:00 | GPR4 deficiency reduces acute intestinal inflammation in a mouse colitis model. GPR4 gene expression is upregulated in inflamed mouse and human intestinal tissues. | 27940273 |
| 2017-12-09 12:47:00 | GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. | 29089376 |
| 2017-07-08 13:04:00 | Collectively, these results posit the acid sensor GPR4 as a novel component of central blood pressure control through interactions with the renin-angiotensin system. | 27681561 |
| 2015-12-26 11:17:00 | knockdown of a proton-sensing G protein-coupled receptor GPR4 markedly reduced CHOP expression and endothelial cell apoptosis after hypoxia exposure. | 25343248 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
GPR4_MOUSE
UniprotKB:
Q8BUD0
UniParc:
UPI0000027F64
EMBL:
AK085829,
BC099398,
CH466639
Ensembl:
ENSMUSG00000044317
KO:
mmu:319197
|
| Nucleutide sequences |
EMBL-CDS:
AAH99398.1,
BAC39547.1,
EDL23124.1
Ensembl_TRS:
ENSMUST00000060225
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000061243
RefSeq:
NP_783599.1
|
| Others |
UniRef100:
UniRef100_Q8BUD0
UniRef90:
UniRef90_Q8BUD0
UniRef50:
UniRef50_P46093
UniGene:
Mm.135984
CCDS:
CCDS20893.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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