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31845 fh

31845

fh

frataxin

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition frataxin

研究结论

Date Results Publications
2018-07-28 10:05:00 we report that frataxin overexpression is sufficient to increase oxidative phosphorylation, modify mitochondrial morphology, alter iron homeostasis and trigger oxidative stress-dependent cell death. 28838288
2017-11-18 10:30:00 The authors show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2). 27343351
2011-11-19 10:59:00 Frataxin overexpression in the nervous system reduces life span, impairs locomotor ability and causes brain degeneration. 21779322
2010-10-04 12:40:00 Strong involvement of glial cells and lipid peroxidation in the generation of Friedreich's ataxia. 20460268
2010-09-20 11:27:00 Defects in axonal transport of mitochondria appear late in development in distal nerve of larvae showing reduced frataxin expression, with retrograde movement preferentially affected. 20739558

名称对应

Type IDs
Synonymous BcDNA:AT09528, CG8971, DFH, Dfh, Dmel\CG8971, X25, dfh
Gene
UniProtKB-ID: FRDA_DROME
UniprotKB: Q9W385
UniParc: UPI00000009E7
EMBL: AE014298, AF208491, AJ002208, AF208492, AY094649
EnsemblGenome: FBgn0030092
KO: dme:Dmel_CG8971
Nucleutide sequences
EMBL-CDS: AAF46449.1, AAM11002.1, CAC20098.1, AAG35732.1, AAG35733.1
Gene_ORFName: CG8971
EnsemblGenome_TRS: FBtr0071348
Protein sequencees
EnsemblGenome_PRO: FBpp0071283
RefSeq: NP_511094.1
Others
UniRef100: UniRef100_Q9W385
UniRef90: UniRef90_Q9W385
UniRef50: UniRef50_Q9W385
UniGene: Dm.2903

全选

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研究热度

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