| Type | Description |
|---|---|
| Definition | frataxin |
| Date | Results | Publications |
|---|---|---|
| 2018-07-28 10:05:00 | we report that frataxin overexpression is sufficient to increase oxidative phosphorylation, modify mitochondrial morphology, alter iron homeostasis and trigger oxidative stress-dependent cell death. | 28838288 |
| 2017-11-18 10:30:00 | The authors show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2). | 27343351 |
| 2011-11-19 10:59:00 | Frataxin overexpression in the nervous system reduces life span, impairs locomotor ability and causes brain degeneration. | 21779322 |
| 2010-10-04 12:40:00 | Strong involvement of glial cells and lipid peroxidation in the generation of Friedreich's ataxia. | 20460268 |
| 2010-09-20 11:27:00 | Defects in axonal transport of mitochondria appear late in development in distal nerve of larvae showing reduced frataxin expression, with retrograde movement preferentially affected. | 20739558 |
| Type | IDs |
|---|---|
| Synonymous | BcDNA:AT09528, CG8971, DFH, Dfh, Dmel\CG8971, X25, dfh |
| Gene |
UniProtKB-ID:
FRDA_DROME
UniprotKB:
Q9W385
UniParc:
UPI00000009E7
EMBL:
AE014298,
AF208491,
AJ002208,
AF208492,
AY094649
EnsemblGenome:
FBgn0030092
KO:
dme:Dmel_CG8971
|
| Nucleutide sequences |
EMBL-CDS:
AAF46449.1,
AAM11002.1,
CAC20098.1,
AAG35732.1,
AAG35733.1
Gene_ORFName:
CG8971
EnsemblGenome_TRS:
FBtr0071348
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0071283
RefSeq:
NP_511094.1
|
| Others |
UniRef100:
UniRef100_Q9W385
UniRef90:
UniRef90_Q9W385
UniRef50:
UniRef50_Q9W385
UniGene:
Dm.2903
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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