| Type | Description |
|---|---|
| Definition | GTPase, IMAP family member 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-16 12:10:00 | Activation of Gimap5-deficient CD4(+) T cells is associated with increased DNA damage and reduced survival that can be overcome by TGF-beta. This leads to selective survival of pathogenic TH17 cells but also TH2 cells in human subjects and mice, ultimately promoting allergic airway disease. | 30616774 |
| 2018-03-31 10:22:00 | Gimap5 is a critical inhibitor of GSK3-beta in the CD4+ T cells. | 29382851 |
| 2016-09-03 11:37:00 | functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. | 27023180 |
| 2016-02-06 11:03:00 | gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] | 25944983 |
| 2014-04-26 11:37:00 | The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5. | 24510501 |
| Type | IDs |
|---|---|
| Synonymous | D630024P16, E230026N22Rik |
| Gene |
UniProtKB-ID:
GIMA5_MOUSE
UniprotKB:
Q8BWF2
UniParc:
UPI0000028FFB
EMBL:
BC095995,
AK052694,
AB126961
Ensembl:
ENSMUSG00000043505
KO:
mmu:317757
|
| Nucleutide sequences |
EMBL-CDS:
BAC35100.1,
BAD06929.1,
AAH95995.1
Ensembl_TRS:
ENSMUST00000055558
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000056820
RefSeq:
NP_778200.1
|
| Others |
UniRef100:
UniRef100_Q8BWF2
UniRef90:
UniRef90_Q8BWF2
UniRef50:
UniRef50_Q96F15-2
UniGene:
Mm.455917
CCDS:
CCDS20114.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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