| Type | Description |
|---|---|
| Definition | Ubr3 ubiquitin ligase |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 12:58:00 | Here, the authors show that a molecular complex identified in Drosophila epidermal differentiation, comprising Mlpt peptides, ubiquitin-ligase Ubr3 and transcription factor Shavenbaby (Svb), represents an ancient developmental module required for early insect embryo patterning. | 30896406 |
| 2017-11-18 12:51:00 | Ubr3 negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. | 27331610 |
| 2017-04-29 12:14:00 | We identified Ubr3, an E3 ubiquitin ligase, as a novel, positive regulator of Hh signaling in Drosophila and vertebrates. Hh signaling regulates the Ubr3-mediated poly-ubiquitination and degradation of Cos2, a central component of Hh signaling. In developing Drosophila eye discs, loss of ubr3 leads to a delayed differentiation of photoreceptors and a reduction in Hh signaling. | 27195754 |
| 2015-07-25 10:40:00 | Ubr3 interacts with DIAP1 and positively regulates DIAP1 activity, possibly by maintaining its active conformation in the apoptosis pathway. | 25146930 |
| Type | IDs |
|---|---|
| Synonymous | CG1530, CG1531, CG42593, Dmel\CG42593, Dmel_CG1530, Dmel_CG1531, UBR3, ubr3 |
| Gene |
UniProtKB-ID:
UBR3_DROME,
M9PDZ8_DROME
UniprotKB:
Q9W3M3,
M9PDZ8
UniParc:
UPI0002944CDB,
UPI0001BFFF0B,
UPI000294413D
EMBL:
AE014298
EnsemblGenome:
FBgn0260970
KO:
dme:Dmel_CG42593
|
| Nucleutide sequences |
EMBL-CDS:
AGB95163.1,
AAF46302.4,
AGB95162.1
Gene_ORFName:
CG42593,
CG42593,
Dmel_CG42593
EnsemblGenome_TRS:
FBtr0331299,
FBtr0301748,
FBtr0331298
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0290962,
FBpp0303731,
FBpp0303730
RefSeq:
NP_572428.3,
NP_001259317.1,
NP_001259318.1
|
| Others |
UniRef100:
UniRef100_Q9W3M3
UniRef90:
UniRef90_Q9W3M3
UniRef50:
UniRef50_Q9W3M3
UniGene:
Dm.18600
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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