| Type | Description |
|---|---|
| Definition | 3-hydroxy-3-methylglutaryl-CoA synthase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:26:00 | Expanding the clinical spectrum of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency with Turkish cases harboring novel HMGCS2 gene mutations and literature review. | 32259399 |
| 2020-07-11 11:46:00 | HMGCS2 expression is significantly reduced in colorectal cancer compared with healthy control, which is inversely correlated with microvessel density in colorectal cancer by immunohistochemistry analysis. What is more, knockdown HMGCS2 expression in HT-29 cells significantly contributed endothelial cell tube formation | 31355161 |
| 2020-06-06 12:17:00 | The results identified HMGCS2 as a downstream target of Wnt/beta-catenin/PPARgamma signaling in intestinal epithelial cells. And, Wnt/beta-catenin/PPARgamma signaling regulates intestinal cell differentiation, at least in part, through regulation of ketogenesis. | 31546785 |
| 2020-04-11 10:25:00 | we screened 46,XY DSD patients with gonadal dysgenesis and identified two unrelated patients with a deletion and a deleterious missense variant in HMGCS2 respectively. However, both variants were heterozygous, suggesting that HMGCS2 might not be the causative gene | 31910233 |
| 2020-01-18 11:32:00 | that HMGCS2 may be capable of predicting the risk of biochemical recurrence in prostate cancer patients after radical prostatectomy | 31176575 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HMCS2_HUMAN,
A0A140VJL2_HUMAN
UniprotKB:
P54868,
A0A140VJL2
UniParc:
UPI000000DA7A,
UPI00019151D6,
UPI00035082D6
EMBL:
GU433940,
CR456850,
U81858,
X83618,
U81853,
U81855,
U81851,
HM005401,
AL589734,
U12789,
BC044217,
CH471122,
U81854,
U81852,
U81856,
AK303777,
U81859,
U81857,
U12788
Ensembl:
ENSG00000134240
KO:
hsa:3158
|
| Nucleutide sequences |
EMBL-CDS:
EAW56709.1,
AAA92673.1,
ADD21696.1,
AAH44217.1,
CAA58593.1,
AAB72036.1,
BAH14049.1,
CAG33131.1,
AAA92674.1,
AEE60999.1
Ensembl_TRS:
ENST00000369406,
ENST00000544913
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000439495,
ENSP00000358414
RefSeq:
XP_011539615.1,
NP_001159579.1,
NP_005509.1
|
| Others |
UniRef100:
UniRef100_P54868
UniRef90:
UniRef90_P54868
UniRef50:
UniRef50_P54868
UniGene:
Hs.59889
CCDS:
CCDS53353.1,
CCDS905.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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