| Type | Description |
|---|---|
| Definition | 3-hydroxy-3-methylglutaryl-CoA reductase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:30:00 | Mesenchymal subtype neuroblastomas are addicted to TGF-betaR2/HMGCR-driven protein geranylgeranylation. | 32612149 |
| 2020-11-28 13:16:00 | The Polymorphism rs2968 of LSS Gene Confers Susceptibility to Age-Related Cataract. | 32877255 |
| 2020-11-21 13:28:00 | Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations. | 32100014 |
| 2020-06-27 12:19:00 | In this study, it's demonstrated that doxorubicin exerts its anti-cancer effect via modulation of cholesterol synthesis through downregulation of HMG-CoA reductase (HMG-CR) expression, which is mediated by the epidermal growth factor receptor(EGFR)-Src pathway. | 30700846 |
| 2020-06-27 11:25:00 | lanosterol is a bona fide endogenous regulator that specifically promotes HMGCR degradation, and that other C4-dimethylated sterol intermediates may regulate both HMGCR degradation and SREBP-2 cleavage | 31455613 |
| Type | IDs |
|---|---|
| Synonymous | LDLCQ3 |
| Gene |
UniProtKB-ID:
HMDH_HUMAN,
A0A024RAP2_HUMAN
UniprotKB:
P04035,
A0A024RAP2
UniParc:
UPI000012C9E2,
UPI0002C5E53D,
UPI000002AB2F
EMBL:
AF273755,
AK296499,
M11058,
AF273757,
AF273758,
AF273765,
AC008897,
AY321356,
AF273762,
AF273754,
AF273756,
AF273763,
AF273759,
AF273764,
BC033692,
AF273760,
CH471084,
AF273761
Ensembl:
ENSG00000113161
KO:
hsa:3156
|
| Nucleutide sequences |
EMBL-CDS:
AAA52679.1,
AAH33692.1,
BAH12375.1,
AAP72015.1,
AAG21343.1,
EAW95754.1,
EAW95755.1
Gene_ORFName:
hCG_1757337
Ensembl_TRS:
ENST00000343975,
ENST00000287936,
ENST00000511206
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000287936,
ENSP00000426745,
ENSP00000340816
RefSeq:
XP_011541661.1,
XP_011541659.1,
XP_011541660.1,
NP_001124468.1,
NP_001351116.1,
NP_000850.1
|
| Others |
UniRef100:
UniRef100_P04035
UniRef90:
UniRef90_P04035
UniRef50:
UniRef50_P04035
UniGene:
Hs.628096,
Hs.643495
CCDS:
CCDS47234.1,
CCDS4027.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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