| Type | Description |
|---|---|
| Definition | insulin receptor substrate 4 |
| Date | Results | Publications |
|---|---|---|
| 2012-07-28 11:06:00 | The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling. | 21955513 |
| 2010-01-21 00:00:00 | At low glucose concentrations (3 mM), PI3'K activation occurred through IRS-2 phosphorylation whereas, in the presence of physiological glucose concentration IRS4 and at high glucose concentrations (15 mM), IRS-1 triggered a proliferative effect. | 17993726 |
| 2010-01-21 00:00:00 | the induced expression of IRS-4 is a compensatory mechanism that plays a role in conditions of liver regeneration | 12774026 |
| 2005-06-03 11:06:00 | IRS-4 is specifically expressed in the adult rat brain in the hypothalamus, medial amygdala, and nucleus accumbens shell region. This differs from IRS-1 and IRS-2 which are more widely expressed in brain. | 10521603 |
| 2003-06-30 13:47:00 | IRS-4 is activated by insulin and IGF-1-like IRS-1 in rat hepatocytes, and the induced expression of IRS-4 is a compensatory mechanism that plays a role in conditions of liver regeneration. | 12774026 |
| Type | IDs |
|---|---|
| Synonymous | IRS-4 |
| Gene | |
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
XP_001056753.2,
XP_235721.7
|
| Others |
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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