| Type | Description |
|---|---|
| Definition | megalencephalic leukoencephalopathy with subcortical cysts 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 11:27:00 | In astrocytes with reduced or increased levels of MLC1 we observe changes in the phosphorylation state of the VRAC subunit LRRC8C. | 30076890 |
| 2016-12-17 10:52:00 | Study discloses an important role for MLC1 in the control of astrocyte growth and in the regulation of pathways that trigger quiescent astrocytes into reactive ones in response to brain injury. It also shows that MLC1 pathological mutations cause loss of its function. | 26908604 |
| 2010-01-21 00:00:00 | findings show that the membrane-associated component of MLC1 (60-64 kDa) localizes in astrocytic lipid rafts together with dystroglycan, syntrophin and caveolin-1, and co-fractionates with the dystrophin-glycoprotein complex in whole rat brain tissue | 18165104 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
D4ABB2_RAT
UniprotKB:
D4ABB2
UniParc:
UPI000155100F
EMBL:
CH474027,
AABR07058660
Ensembl:
ENSRNOG00000032871
KO:
rno:315215
|
| Nucleutide sequences |
EMBL-CDS:
EDL76527.1
Gene_ORFName:
rCG_59299
Ensembl_TRS:
ENSRNOT00000055879
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000052732
RefSeq:
XP_006242263.1,
NP_001101575.1,
XP_017450367.1
|
| Others |
UniRef100:
UniRef100_D4ABB2
UniRef90:
UniRef90_Q8VHK5
UniRef50:
UniRef50_Q15049
UniGene:
Rn.98819
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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