| Type | Description |
|---|---|
| Definition | holocarboxylase synthetase |
| Date | Results | Publications |
|---|---|---|
| 2017-10-07 11:00:00 | The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed. | 28564555 |
| 2015-02-14 13:27:00 | The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1, HDAC2 and HDAC7 | 24239178 |
| 2014-09-27 12:05:00 | Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1) contribute toward transcriptional repression of repeats, presumably increasing genome stability. | 24840043 |
| 2014-05-17 15:40:00 | study characterizes three functional promoters in the human HLCS gene | 24075901 |
| 2014-03-22 10:06:00 | HLCS interacts physically with the DNA methyltransferase DNMT1 and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin. | 23624957 |
| Type | IDs |
|---|---|
| Synonymous | HCS |
| Gene |
UniProtKB-ID:
BPL1_HUMAN
UniprotKB:
P50747
UniParc:
UPI0000126A8C
EMBL:
AK314189,
AK307940,
AP000698,
AP001726,
D87328,
AP000703,
AP001727,
AP000697,
CH471079,
D23672,
AP000701,
AB063285,
BC060787,
AJ001864
Ensembl:
ENSG00000159267
KO:
hsa:3141
|
| Nucleutide sequences |
EMBL-CDS:
EAX09732.1,
BAA95511.1,
BAA89434.1,
EAX09731.1,
BAB68550.1,
BAA13332.1,
AAH60787.1,
BAA95510.1,
BAG36868.1,
CAA05056.1,
BAA04902.1
Ensembl_TRS:
ENST00000399120,
ENST00000612277,
ENST00000336648
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382071,
ENSP00000479939,
ENSP00000338387
RefSeq:
NP_001339443.1,
XP_024307833.1,
XP_011527842.1,
XP_024307834.1,
XP_006724058.1,
XP_011527840.1,
NP_001339444.1,
NP_001339447.1,
XP_011527841.1,
NP_001339445.1,
NP_001229713.1,
NP_000402.3,
XP_016883819.1,
NP_001229714.1,
NP_001339446.1
|
| Others |
UniRef100:
UniRef100_P50747
UniRef90:
UniRef90_P50747
UniRef50:
UniRef50_P50747
UniGene:
Hs.371350,
Hs.732538
CCDS:
CCDS13647.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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