Prdm2 - PR/SET domain 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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313678 Prdm2

基因描述

Type	Description
Definition	PR/SET domain 2

研究结论

Date	Results	Publications
2018-07-14 10:11:00	Findings indicate that PRDM2-mediated reprogramming of the genome in neurons of the dorsomedial prefrontal cortex is involved in increasing alcohol self-administration, compulsive-like drinking and stress-induced relapse. This broad spectrum of actions provides a strong rationale to explore PRMD2 itself or some of its downstream targets as candidate targets for novel alcoholism medications.	27573876

名称对应

Type	IDs
Synonymous	Riz
Gene	UniProtKB-ID: PRDM2_RAT, F1LQ66_RAT UniprotKB: Q63755, F1LQ66 UniParc: UPI0000199F99, UPI00000E8762 EMBL: U17837, AABR07050345, AABR07050344 Ensembl: ENSRNOG00000033522 KO: rno:313678
Nucleutide sequences	EMBL-CDS: AAA74468.1 Ensembl_TRS: ENSRNOT00000041175, ENSRNOT00000078237
Protein sequencees	Ensembl_PRO: ENSRNOP00000072686, ENSRNOP00000046011 RefSeq: XP_017448917.1, XP_017448916.1, XP_006239399.1, NP_001071116.2, XP_017448915.1, XP_017448914.1, XP_008762477.1
Others	UniRef100: UniRef100_Q63755, UniRef100_F1LQ66 UniRef90: UniRef90_Q63755 UniRef50: UniRef50_Q63755 UniGene: Rn.202632

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
27573876	Dependence-induced increase of alcohol self-administration and compulsive drinking mediated by the histone methyltransferase PRDM2. Mol. Psychiatry E Barbier , A L Johnstone , B B Khomtchouk , J D Tapocik , C Pitcairn , F Rehman , E Augier , A Borich , J R Schank , C A Rienas , D J Van Booven , H Sun , D NÃ¤tt , C Wahlestedt , M Heilig	2017-12-01	-
23200123	Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol. Cell Joshua C Black , Capucine Van Rechem , Johnathan R Whetstine	2012-11-30	Kdm6a, Kmt2d, Prdm16, Kdm4dl1, LOC100909949, LOC100911180, Kmt2b, Jmjd1c, Smyd2, Whsc1l1, Smyd1, Kdm4c, Kdm4b, Kdm2b, Kdm5b, Prdm8, Nsd1, Phf2, Kdm1b, Prdm6, Kmt5c, Kdm8, Ash1l, Kmt2e, Ezh2, Kdm3a, Kdm5a, Kdm4a, Prdm2, Kmt2a, Setd2, Phf8, Kdm5c, Kmt5b, Kdm2a, Ehmt2, Ehmt1, Dot1l, Kdm6b, Suv39h2, Prdm9, Smyd3, Kdm1a, Kmt2c, Kdm3b, Kdm7a, Setd7
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
11544182	Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily. Genes Dev. G Steele-Perkins , W Fang , X H Yang , M Van Gele , T Carling , J Gu , I M Buyse , J A Fletcher , J Liu , R Bronson , R B Chadwick , A de la Chapelle , X Zhang , F Speleman , S Huang	2001-09-01	Prdm2, Esr1, Trp53, ESR1, PRDM2
10706618	The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action. Proc Natl Acad Sci U S A C Abbondanza , N Medici , V Nigro , V Rossi , L Gallo , G Piluso , A Belsito , A Roscigno , P Bontempo , A A Puca , A M Molinari , B Moncharmont , G A Puca	2000-03-28	-
9334209	Transcriptional repression mediated by the PR domain zinc finger gene RIZ. J Biol Chem M Xie , G Shao , I M Buyse , S Huang	1997-10-17	-
8654390	cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene. Eur. J. Biochem. Y Muraosa , K Takahashi , M Yoshizawa , S Shibahara	1996-02-01	-
7538672	The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proc. Natl. Acad. Sci. U.S.A. I M Buyse , G Shao , S Huang	1995-05-09	-

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