| Type | Description |
|---|---|
| Definition | Rap1 GTPase-activating protein |
| Date | Results | Publications |
|---|---|---|
| 2019-07-27 12:45:00 | the present study shows that down-regulated miR-182-5p promotes the proliferation and differentiation of osteoblasts in Osteoporosis (OP) rats through Rap1/MAPK signaling pathway activation by up-regulating ADCY6, which may represent a novel target for OP treatment | 30413613 |
| 2017-08-19 11:59:00 | Here, we demonstrate that 1) stimulation of cAMP production deactivates ischemia-reperfusion-induced hyperpermeability in muscle and endothelial cells; 2) VEGF mRNA expression is not enhanced by brief ischemia, suggesting that VEGF mechanisms do not activate immediate postischemic hyperpermeability; and 3) deactivation mechanisms operate via cAMP-exchange protein activated by cAMP 1-Rap1 to restore integrity of the endot | 28476918 |
| 2017-08-05 10:11:00 | results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity | 27612188 |
| 2012-09-25 05:45:00 | Disruption of the DEP-dependent subcellular targeting of Epac abolished cAMP-Epac-mediated Rap1 activation and thyroid-stimulating hormone-mediated cell proliferation | 18063584 |
| 2012-09-25 05:45:00 | The transport of the signaling complex containing the p75 receptor and Rap1 may play a role in the effect of MAG (myelin-associated glycoprotein). | 18049479 |
| Type | IDs |
|---|---|
| Synonymous | Rap1ga1 |
| Gene |
UniProtKB-ID:
F1LV89_RAT,
Q5EB70_RAT
UniprotKB:
F1LV89,
Q5EB70
UniParc:
UPI0000DA28A3,
UPI00004CEA7D
EMBL:
AC119102,
BC089979
Ensembl:
ENSRNOG00000013825
KO:
rno:313644
|
| Nucleutide sequences |
EMBL-CDS:
AAH89979.1
Ensembl_TRS:
ENSRNOT00000046802
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000048749
RefSeq:
XP_017448899.1,
XP_017448902.1,
XP_017448900.1,
XP_017448897.1,
XP_017448901.1,
XP_017448903.1,
XP_017448898.1,
XP_006239255.2,
NP_001094183.1,
XP_006239251.2
|
| Others |
UniRef100:
UniRef100_F1LV89
UniRef90:
UniRef90_F1LV89
UniRef50:
UniRef50_P47736-2
UniGene:
Rn.18036
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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