| Type | Description |
|---|---|
| Definition | HLF transcription factor, PAR bZIP family member |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:28:00 | Downregulation of the circadian rhythm regulator HLF promotes multiple-organ distant metastases in non-small cell lung cancer through PPAR/NF-kappab signaling. | 32289442 |
| 2020-01-18 11:19:00 | our data establish HLF as a crucial transcription factor in triple-mutated AML, which modulates cell cycle dynamics and maintains the CD34+GPR56+ LSC-enriched compartment in this high-risk genetic subgroup. | 31076446 |
| 2019-10-19 11:52:00 | Our findings uncovered HLF as a novel oncofetal protein and revealed the crucial role of the HLF/c-Jun axis in HCC development and sorafenib response, rendering HLF as an optimal target for the prevention and intervention of HCC | 31118247 |
| 2017-08-12 11:59:00 | Poly (ADP-ribose) polymerase inhibitors selectively induce cytotoxicity in TCF3-HLF-positive leukemic cells. | 27894958 |
| 2017-02-18 12:23:00 | HLF-mediated miR-132 directly suppresses TTK expression, thus exerting inhibitory effects on cancer cell proliferation, metastasis and radioresistance. | 27522003 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
HLF_HUMAN
UniprotKB:
Q16534
UniParc:
UPI0000001C51,
UPI0000469734
EMBL:
BC036093,
AK290043,
CR541672,
X68985,
AK315079,
M95585,
CH471109,
AC007638,
M95586
Ensembl:
ENSG00000108924
KO:
hsa:3131
|
| Nucleutide sequences |
EMBL-CDS:
EAW94544.1,
BAG37547.1,
CAG46473.1,
CAA48777.1,
AAH36093.1,
AAA52675.1,
AAA58445.1,
BAF82732.1
Ensembl_TRS:
ENST00000430986,
ENST00000226067,
ENST00000575345,
ENST00000573945
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000460296,
ENSP00000226067,
ENSP00000402496,
ENSP00000460572
RefSeq:
NP_001317304.1,
XP_005257326.1,
NP_002117.1,
XP_011523007.1
|
| Others |
UniRef100:
UniRef100_Q16534
UniRef90:
UniRef90_Q16534
UniRef50:
UniRef50_Q16534
UniGene:
Hs.196952
CCDS:
CCDS82164.1,
CCDS11585.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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