Lrp6 - LDL receptor related protein 6-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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312781 Lrp6

基因描述

Type	Description
Definition	LDL receptor related protein 6

研究结论

Date	Results	Publications
2019-11-23 10:47:00	LRP6 regulates alternative pre-mRNA splicing.	30070011
2018-10-13 10:43:00	knockdown of LRP6 inhibited the cell viability by activation of Drp1 in glucose deprived-cardiomyocytes.	29864925
2018-08-25 11:28:00	LRP6 acts as a scaffold protein in cardiac gap junction assembly and intracellular protein trafficking.	27250245
2017-12-16 12:06:00	Authors demonstrate for the first time novel neuroprotective function of REST in prion diseases and hypothesise that the LRP6-Wnt-beta-catenin/REST signaling plays critical and collaborative roles in neuroprotection.	26919115
2016-02-13 10:44:00	GSK3beta is activated and p-LRP6 is down-regulated in kidneys of diabetic rats. These abnormalities were prevented by treatment with green tea.	25655048

名称对应

Type	IDs
Gene	UniProtKB-ID: A0A0G2K0H3_RAT, D3ZUH9_RAT UniprotKB: A0A0G2K0H3, D3ZUH9 UniParc: UPI000157F317, UPI0000506B4D EMBL: CH473964, AABR07062321, AABR07062322 Ensembl: ENSRNOG00000006338 KO: rno:312781
Nucleutide sequences	EMBL-CDS: EDM01658.1 Gene_ORFName: rCG_29933 Ensembl_TRS: ENSRNOT00000082102, ENSRNOT00000066575
Protein sequencees	Ensembl_PRO: ENSRNOP00000071445, ENSRNOP00000063261 RefSeq: XP_017448147.1, NP_001101362.1
Others	UniRef100: UniRef100_D3ZUH9, UniRef100_A0A0G2K0H3 UniRef90: UniRef90_O75581, UniRef90_D3ZUH9 UniRef50: UniRef50_O75581, UniRef50_D3ZUH9 UniGene: Rn.229041

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mRNA

Protein

UniprotKB

Description

Refseq

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全选

Pubmed编号	文献信息	发表日期	相关基因
30070011	Low-density lipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing. J Cell Mol Med Tianyou Yuan , Shiyi Wang , Chaoyue Hu , Yufei Wu , Dandan Liang , Li Li , Yi Liu , Jun Li , Yi-Han Chen	2018-10-01	-
29864925	Knockdown of LRP6 activates Drp1 to inhibit survival of cardiomyocytes during glucose deprivation. Biomed Pharmacother Zhidan Chen , Yang Li , Guoliang Jiang , Chunjie Yang , Ying Wang , Xiang Wang , Bo Fang , Guoping Zhang , Yongxin Sun , Juying Qian , Hui Gong , Yunzeng Zou	2018-07-01	-
27250245	LRP6 acts as a scaffold protein in cardiac gap junction assembly. Nat Commun Jun Li , Changming Li , Dandan Liang , Fei Lv , Tianyou Yuan , Erlinda The , Xiue Ma , Yahan Wu , Lixiao Zhen , Duanyang Xie , Shiyi Wang , Yuan Liu , Jian Huang , Jingyi Shi , Yi Liu , Dan Shi , Liang Xu , Li Lin , Luying Peng , Jianmin Cui , Weidong Zhu , Yi-Han Chen	2016-06-02	-
26919115	REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-Î²-catenin signaling. Oncotarget Zhiqi Song , Ting Zhu , Xiangmei Zhou , Paul Barrow , Wei Yang , Yongyong Cui , Lifeng Yang , Deming Zhao	2016-03-15	-
25655048	Reduced LRP6 expression and increase in the interaction of GSK3Î² with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea. J. Nutr. Biochem. E B Peixoto , A Papadimitriou , D A T Teixeira , C Montemurro , D A Duarte , K C Silva , P P Joazeiro , J M Lopes de Faria , J B Lopes de Faria	2015-04-01	Tp53, Lrp6, Gsk3b
23481549	Inhibition of LRP5/6-mediated Wnt/Î²-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats. Pediatr. Res. Deepthi Alapati , Min Rong , Shaoyi Chen , Cuihong Lin , Yonghe Li , Shu Wu	2013-06-01	-
23845000	Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. J. Biomed. Sci. Aseem Hussain , Minh Luong , Apryl Pooley , Britto P Nathan	2013-01-01	-
22899650	LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum Mol Genet Daniel C Berwick , Kirsten Harvey	2012-11-15	-
21984209	Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat. Struct. Mol. Biol. Zhihong Cheng , Travis Biechele , Zhiyi Wei , Seamus Morrone , Randall T Moon , Liguo Wang , Wenqing Xu	2011-10-09	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-

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