| Type | Description |
|---|---|
| Definition | Phosphoglycerate mutase 5 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-19 11:00:00 | The authors show that developmental mitochondrial unfolded protein response is necessary and sufficient to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. Developmental mitochondrial stress leads to activation of FoxO, via Apoptosis Signal-regulating Kinase 1 (ASK1) and Jun-N-terminal Kinase (JNK). | 28891792 |
| 2012-08-04 10:23:00 | the mushroom body may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for heat shock resistance. | 22347370 |
| 2011-04-02 10:04:00 | PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria. | 21151955 |
| Type | IDs |
|---|---|
| Synonymous | CG14816, DPGAM5, Dmel\CG14816, EG:63B12.4, PGAM5, dPGAM5 |
| Gene |
UniProtKB-ID:
PGAM5_DROME,
X2JC94_DROME
UniprotKB:
O46084,
X2JC94
UniParc:
UPI0002B8CD6A,
UPI000007CF75
EMBL:
AL021106,
AY060608,
AE014298
EnsemblGenome:
FBgn0023517
KO:
dme:Dmel_CG14816
|
| Nucleutide sequences |
EMBL-CDS:
AAF45678.1,
CAA15939.1,
AAL28156.2,
AHN59266.1
Gene_ORFName:
CG14816,
CG14816,
Dmel_CG14816
EnsemblGenome_TRS:
FBtr0070366,
FBtr0339601
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0070350,
FBpp0308673
RefSeq:
NP_001284795.1,
NP_569951.1
|
| Others |
UniRef100:
UniRef100_X2JC94,
UniRef100_O46084
UniRef90:
UniRef90_O46084
UniRef50:
UniRef50_O46084
UniGene:
Dm.3943
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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