| Type | Description |
|---|---|
| Definition | trio Rho guanine nucleotide exchange factor |
| Date | Results | Publications |
|---|---|---|
| 2018-01-13 12:56:00 | In accordance with pathological increases or decreases in glutamatergic neurotransmission observed in animal models of autism spectrum disorder, we find that Trio mutations result in either reduced synaptic AMPA receptor expression or enhanced glutamatergic synaptogenesis. Together, our findings implicate both excessive and reduced Trio activity and the resulting synaptic dysfunction in ASD-related pathogenesis. | 28928363 |
| 2016-12-17 10:53:00 | TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function. | 26721934 |
| 2015-12-19 10:23:00 | These findings demonstrate that Hsc70 chaperone activity is required for Rac1 activation by Trio and this function underlies netrin-1/DCC-dependent axon outgrowth and guidance. | 26323693 |
| 2014-08-09 11:38:00 | Describe here an invadopodia disassembly model, where a signalling axis involving TrioGEF, Rac1, Pak1, and phosphorylation of cortactin, causes invadopodia dissolution. | 24859002 |
| 2013-03-30 12:17:00 | Trio(Y2622) phosphorylation is essential for the regulation of the DCC/Trio signaling complex in cortical neurons during netrin-1-mediated axon outgrowth. | 23230270 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
TRIO_RAT
UniprotKB:
F1M0Z1
UniParc:
UPI0003D1011B
EMBL:
AABR07008948,
AABR07008947
|
| Nucleutide sequences | |
| Protein sequencees |
RefSeq:
XP_006232152.1,
XP_017450563.1,
XP_017450562.1,
XP_017446702.1,
XP_017446701.1,
XP_006232153.1,
XP_003749274.1,
XP_006224115.1,
XP_003753588.1,
XP_006224114.1,
NP_001101128.2
|
| Others |
UniRef100:
UniRef100_F1M0Z1
UniRef90:
UniRef90_O75962
UniRef50:
UniRef50_O75962
UniGene:
Rn.222545,
Rn.226288
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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