| Type | Description |
|---|---|
| Definition | beta amyloid protein precursor-like |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 10:30:00 | APPL is essential for visual working memory. Interestingly, this short-term memory declines rapidly with age, and this is accompanied by enhanced processing of APPL in aged flies. Furthermore, reducing secretase-mediated proteolytic processing of APPL can prevent the age-related memory loss, whereas overexpression of the secretases aggravates the aging effect. | 29478851 |
| 2017-11-11 11:14:00 | Results show that Drosophila largely mimics transgenic amyloid beta in various phenotypes which include eye degeneration, reduced longevity and motor neuron deficit functions. This is the first report showing comparable phenotypes between APPL and amyloid beta in Alzheimer's disease model of Drosophila. | 28336338 |
| 2017-04-29 11:00:00 | Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate recycling. | 28314820 |
| 2016-05-14 12:35:00 | memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide. | 26274614 |
| 2016-01-16 12:20:00 | The results of this study showed that increased production of the endogenous Drosophila Amyloid Intracellular Domain (dAICD) caused disruption of circadian rest-activity rhythms during aging. | 25766673 |
| Type | IDs |
|---|---|
| Synonymous | APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\CG7727, EG:65F1.5, appl, dAPPl, dAbeta |
| Gene |
UniProtKB-ID:
A4_DROME,
M9NE22_DROME,
M9NEM2_DROME,
M9NFQ0_DROME,
M9NDH5_DROME,
M9NGF6_DROME
UniprotKB:
P14599,
M9NE22,
M9NEM2,
M9NFQ0,
M9NDH5,
M9NGF6
UniParc:
UPI000237F72E,
UPI000237F730,
UPI0000125046,
UPI000237F72D,
UPI000237F72F,
UPI000237F731
EMBL:
AE014298,
AL031883,
X55774,
AL022139,
J04516,
AF181628,
X55775
EnsemblGenome:
FBgn0000108
KO:
dme:Dmel_CG7727
|
| Nucleutide sequences |
EMBL-CDS:
CAA18093.1,
CAA21409.1,
CAA39294.1,
AAA28874.1,
AAF45520.2,
AAD55414.1,
AFH07164.1,
AFH07165.1,
AFH07168.1,
AFH07167.1,
AFH07166.1
Gene_ORFName:
CG7727,
Dmel_CG7727,
CG7727,
Dmel_CG7727,
CG7727,
CG7727,
Dmel_CG7727,
Dmel_CG7727,
CG7727,
CG7727,
Dmel_CG7727
EnsemblGenome_TRS:
FBtr0070109,
FBtr0307291,
FBtr0307292,
FBtr0307295,
FBtr0307294,
FBtr0307293
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0070104,
FBpp0298292,
FBpp0298293,
FBpp0298296,
FBpp0298295,
FBpp0298294
RefSeq:
NP_001245451.1,
NP_001245448.1,
NP_001245452.1,
NP_001245449.1,
NP_001245450.1,
NP_476626.2
|
| Others |
UniRef100:
UniRef100_M9NE22,
UniRef100_M9NEM2,
UniRef100_P14599,
UniRef100_M9NDH5,
UniRef100_M9NGF6,
UniRef100_M9NFQ0
UniRef90:
UniRef90_P14599,
UniRef90_M9NE22,
UniRef90_M9NGF6
UniRef50:
UniRef50_P14599
UniGene:
Dm.4862
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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