| Type | Description |
|---|---|
| Definition | leucine carboxyl methyltransferase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:07:00 | Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice. | 32341098 |
| 2019-01-26 12:33:00 | Loss of Lcmt1 expression is associated with severe defects in fetal liver hematopoiesis. | 29735529 |
| 2017-05-20 10:58:00 | LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function. | 27507813 |
| 2014-02-08 10:08:00 | In LCMT1 deficiency enzyme activity and methylation of PP2A are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A methyltransferase. | 23840384 |
| 2011-01-08 10:31:00 | Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization. | 21044074 |
| Type | IDs |
|---|---|
| Synonymous | AL033290, LCMT-1, Lcmt |
| Gene |
UniProtKB-ID:
A2RTH5_MOUSE
UniprotKB:
A2RTH5
UniParc:
UPI00001E4230
EMBL:
AC121956,
BC132507,
BC132509
Ensembl:
ENSMUSG00000030763
|
| Nucleutide sequences |
EMBL-CDS:
AAI32508.1,
AAI32510.1
Ensembl_TRS:
ENSMUST00000033025
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033025
RefSeq:
NP_001341979.1,
XP_030098526.1,
NP_079580.2
|
| Others |
UniRef100:
UniRef100_A2RTH5
UniRef90:
UniRef90_Q6P4Z6
UniRef50:
UniRef50_Q6P4Z6
UniGene:
Mm.260527
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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