| Type | Description |
|---|---|
| Definition | secreted frizzled-related protein 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:23:00 | Reduction of Secreted Frizzled-Related Protein 5 Drives Vascular Calcification through Wnt3a-Mediated Rho/ROCK/JNK Signaling in Chronic Kidney Disease. | 32429518 |
| 2020-05-02 12:04:00 | Central Sfrp5 signaling activates a previously unappreciated InsR-Akt-PI3k-KATP channel pathway in the hypothalamus and brain-hepatic vagus neurocircuitry to decrease hepatic glucose production and VLDL-triglyceride secretion. | 31770545 |
| 2019-12-28 12:05:00 | Sfrp5 reduces markers of cell proliferation, but increases in parallel dose-dependently glucose-stimulated insulin secretion in INS-1E cells | 30921355 |
| 2019-02-16 10:45:00 | the present results suggested that SFRP5 may inhibit SMC proliferation, migration and inflammation by suppressing the Wnt/bcatenin and p38/mitogenactivated protein kinase signaling pathways. | 30221661 |
| 2017-06-10 11:42:00 | Sfrp5 level was significantly reduced in high glucose-treated INS-1 cells, primary rat beta-cells, and islets isolated from glucose-infused rats. Overexpression of SFRP5 diminished glucose-stimulated proliferation in both INS-1 cells and primary beta-cells, with a concomitant inhibition of the Wnt signaling pathway and decreased cyclin D2 expression. | 26869333 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
D3ZTV6_RAT
UniprotKB:
D3ZTV6
UniParc:
UPI0000180C03
EMBL:
CH473986,
AABR07006871
Ensembl:
ENSRNOG00000014940
KO:
rno:309377
|
| Nucleutide sequences |
EMBL-CDS:
EDL94235.1
Gene_ORFName:
rCG_57605
Ensembl_TRS:
ENSRNOT00000020182
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000020182
RefSeq:
NP_001101061.1
|
| Others |
UniRef100:
UniRef100_D3ZTV6
UniRef90:
UniRef90_Q9WU66
UniRef50:
UniRef50_Q9WU66
UniGene:
Rn.40184
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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