| Type | Description |
|---|---|
| Definition | egl-9 family hypoxia-inducible factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:38:00 | Prolyl hydroxylase 2 silencing enhances the paracrine effects of mesenchymal stem cells on necrotizing enterocolitis in an NF-kappaB-dependent mechanism. | 32179740 |
| 2020-06-06 13:37:00 | he above results indicated that direct peritoneal resuscitation with pyruvate showed effective protection to ischemia-reperfusion of the spinal cord through activating autophagy via acting on PHD2 and its downstream HIF-1alpha/BNIP3 pathway. | 31998438 |
| 2019-07-06 10:51:00 | Overexpression of prolyl-hydroxylase 2 (PHD2) transgene, a predominant isoform of PHDs in renal tubules, to reduce HIF-1alpha level significantly attenuated albumin-induced increases in TIMP-1 and collagen-I levels. These results suggest that albumin-induced oxidative stress inhibits PHD activity to accumulate HIF-1alpha, which mediates albumin-induced profibrotic effects in renal tubular cells | 29158549 |
| 2019-03-30 11:01:00 | Our data suggests that mitochondrial stress-mediated elevations in PHD2 interaction with the p23-hsp90 complex have detrimental effects on the survival of DAergic neurons, while p23 inhibition is neuroprotective. | 29471019 |
| 2019-01-05 11:54:00 | GLA supplementation regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DMBA induced mammary gland carcinoma. | 29355756 |
| Type | IDs |
|---|---|
| Synonymous | HIF-PH2, HPH-2, PHD-2, PHD2 |
| Gene |
UniProtKB-ID:
EGLN1_RAT
UniprotKB:
P59722
UniParc:
UPI0003D0F178
EMBL:
BC081694,
AY228140
KO:
rno:308913
|
| Nucleutide sequences |
EMBL-CDS:
AAO34711.1,
AAH81694.1
|
| Protein sequencees |
RefSeq:
XP_002725482.2,
XP_008770901.1
|
| Others |
UniRef100:
UniRef100_P59722
UniRef90:
UniRef90_P59722
UniRef50:
UniRef50_P59722
UniGene:
Rn.44718,
Rn.232203
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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