| Type | Description |
|---|---|
| Definition | apelin |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 11:38:00 | Apelin shorten QT interval by inhibiting Kir2.1/inward rectifier potassium currents via a PI3K way which is the mechanism of anti-acute myocardial infarction. | 31349969 |
| 2020-04-11 12:29:00 | Study identified neutral endopeptidase (NEP) that is upregulated in human abdominal aortic aneurysm (AAA) tissue as a major enzyme that metabolizes and inactivates APLN17 peptide. NEP cleavage resistant APLN17 analog ameliorated Ang II-mediated adverse aortic remodeling and AAA formation in mouse model of AAA. Study defines a critical role of APLN in AAA formation through induction of ACE2 and protection of vascular SMCs. | 31189595 |
| 2020-03-28 10:31:00 | KLF4 plays a key role in inhibiting hepatocellular steatosis in acute liver injury, and that its mechanism might be the inhibition of the apelin signaling pathway. | 31687083 |
| 2020-02-08 10:49:00 | The apelin knockout mice exhibited decreased expression of substrate metabolism-associated genes/proteins, impaired glucose tolerance, and reduced exercise capacity compared to wild-type mice, and all of these effects were rescued by hypoxia. | 30868058 |
| 2020-01-25 11:47:00 | Apelin-13 regulates LPS-induced N9 microglia polarization involving signaling pathway. Apelin-13 ameliorated neuroinflammation by shifting N9 microglial M1 polarization toward the M2 phenotype, the underlying mechanism of which may be related to duanyu18133 signals. | 31255353 |
| Type | IDs |
|---|---|
| Synonymous | 6030430G11Rik, Apel |
| Gene |
UniProtKB-ID:
APEL_MOUSE,
Q544B5_MOUSE
UniprotKB:
Q9R0R4,
Q544B5
UniParc:
UPI000000101D
EMBL:
BC020015,
AB023494,
AJ290423,
AK042076,
DQ832282
Ensembl:
ENSMUSG00000037010
KO:
mmu:30878
|
| Nucleutide sequences |
EMBL-CDS:
AAH20015.1,
BAA84976.1,
CAC83678.1,
ABI30216.1,
BAC31156.1
Ensembl_TRS:
ENSMUST00000039026
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000046012
RefSeq:
NP_038940.1
|
| Others |
UniRef100:
UniRef100_Q9R0R4
UniRef90:
UniRef90_Q9R0R3
UniRef50:
UniRef50_Q9R0R3
UniGene:
Mm.29262
CCDS:
CCDS40958.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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