| Type | Description |
|---|---|
| Definition | phosphoinositide-3-kinase regulatory subunit 4 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-18 11:00:00 | The mutations in VPS15 are associated with cortical atrophy and epilepsy in humans. | 29311744 |
| 2018-09-29 10:13:00 | A missense mutation in PIK3R4 (phosphoinositide 3-kinase regulatory subunit 4, named VPS15) in a family with a ciliopathy phenotype is identified. Besides being required for trafficking and autophagy, we show that VPS15 regulates primary cilium length in human fibroblasts. | 27882921 |
| 2017-10-28 12:17:00 | Both Danon Disease and glycogen storage disease type II show accumulation and altered localization of VPS15 in autophagy-incompetent fibers. However, TFEB displays a different pattern between these two lysosomal storage diseases | 28102838 |
| 2015-08-01 12:03:00 | High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. | 25840748 |
| 2011-01-29 10:58:00 | A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. | 20643123 |
| Type | IDs |
|---|---|
| Synonymous | VPS15, p150 |
| Gene |
UniProtKB-ID:
PI3R4_HUMAN
UniprotKB:
Q99570
UniParc:
UPI0000071EF3
EMBL:
BC127106,
BC110318,
Y08991
Ensembl:
ENSG00000196455
KO:
hsa:30849
|
| Nucleutide sequences |
EMBL-CDS:
AAI27107.1,
AAI10319.1,
CAA70176.1
Ensembl_TRS:
ENST00000356763
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000349205
RefSeq:
NP_055417.1
|
| Others |
UniRef100:
UniRef100_Q99570
UniRef90:
UniRef90_Q99570
UniRef50:
UniRef50_Q99570
UniGene:
Hs.149032
CCDS:
CCDS3067.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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