| Type | Description |
|---|---|
| Definition | helicase, lymphoid specific |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:21:00 | CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats. | 33082427 |
| 2021-01-02 12:53:00 | A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association. | 33170271 |
| 2020-10-10 13:03:00 | Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination. | 32727902 |
| 2020-06-27 11:57:00 | Glioblastoma stem cells (GSCs) preferentially expressed HELLS compared with their differentiated tumor progeny and normal brain cells. Elevated HELLS expression associated with poor prognosis of glioma patients. HELLS interacts with E2F3 and MYC to regulate gene expression critical to GSC proliferation. HELLS expression strongly correlated with targets of E2F3 and MYC transcriptional activity in glioblastoma patients. | 30779712 |
| 2020-06-20 11:14:00 | By altering the nucleosome occupancy at the nucleosome-free region and enhancer, HELLS epigenetically suppresses multiple tumor suppressor genes to promote hepatocellular carcinoma progression. | 30516846 |
| Type | IDs |
|---|---|
| Synonymous | ICF4, LSH, Nbla10143, PASG, SMARCA6 |
| Gene |
UniProtKB-ID:
HELLS_HUMAN,
Q76H82_HUMAN,
A0A087WSW7_HUMAN,
Q0VGL2_HUMAN,
A0A0B4J1V9_HUMAN,
F6XU50_HUMAN
UniprotKB:
Q9NRZ9,
Q76H82,
A0A087WSW7,
Q0VGL2,
A0A0B4J1V9,
F6XU50
UniParc:
UPI0000D4B3E8,
UPI000023B7CA,
UPI000023B7CD,
UPI000047C58A,
UPI000023B7CE,
UPI0000DBE193,
UPI000023B7CF,
UPI00003B5C2C,
UPI0000D4B3E9,
UPI000023B7CC,
UPI000023B7C8,
UPI000023B7CB,
UPI000023B7C9,
UPI000006F63A
EMBL:
AB102721,
AB113249,
BC030963,
AL138759,
AB102716,
AB074174,
BC015477,
AB102719,
AY007108,
BX538033,
AF155827,
AB102718,
AB102717,
BC029381,
AK314485,
CH471066,
AB102720,
BC105606,
BC031004,
AB102722
Ensembl:
ENSG00000119969
KO:
hsa:3070
|
| Nucleutide sequences |
EMBL-CDS:
BAD10846.1,
BAD10847.1,
BAG37088.1,
BAD10845.1,
CAD97978.1,
AAH29381.1,
AAG01987.1,
AAF82262.1,
BAE45737.1,
BAD24805.1,
BAD10850.1,
BAD10848.1,
BAD10849.1,
EAW50035.1,
AAH30963.1,
AAH15477.1,
AAH31004.1,
BAD10844.1,
EAW50029.1,
AAI05607.1,
EAW50027.1,
EAW50037.1
Gene_ORFName:
Nbla10143,
hCG_39170,
hCG_39170,
hCG_39170
Ensembl_TRS:
ENST00000348459,
ENST00000394045,
ENST00000630929,
ENST00000371332,
ENST00000394036,
ENST00000239026
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377609,
ENSP00000239027,
ENSP00000485823,
ENSP00000360383,
ENSP00000377601,
ENSP00000239026
RefSeq:
NP_001276003.1,
NP_001276000.1,
NP_001276001.1,
NP_001276004.1,
NP_001275998.1,
XP_024303736.1,
NP_001275996.1,
NP_001275999.1,
NP_001275997.1,
NP_001276002.1,
NP_060533.2,
XP_024303735.1
|
| Others |
UniRef100:
UniRef100_A0A0B4J1V9,
UniRef100_A0A087WSW7,
UniRef100_Q0VGL2,
UniRef100_Q9NRZ9,
UniRef100_Q76H82
UniRef90:
UniRef90_Q9NRZ9,
UniRef90_A0A2I2Z0H9,
UniRef90_A0A087WSW7,
UniRef90_Q76H82
UniRef50:
UniRef50_A0A337S690,
UniRef50_Q60848
UniGene:
Hs.655830
CCDS:
CCDS7434.1,
CCDS73163.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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