| Type | Description |
|---|---|
| Definition | receptor interacting serine/threonine kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:54:00 | Heat stress induces RIP1/RIP3-dependent necroptosis through the MAPK, NF-kappaB, and c-Jun signaling pathways in pulmonary vascular endothelial cells. | 32471717 |
| 2018-12-22 11:27:00 | Ischemia induces an up-regulation of RIP1K and an enhancement of RIP1K-RIP3K complex formation in neurons and astrocytes. Inhibition of RIP1K increases ischemia-induced reduction in MAP2 or GFAP and decreases ischemia-induced neuronal or astrocytic cell necrosis in the ischemic cortex, and directly protects OGD-induced neuronal or astrocytic cell death. Nec-1 blocks RIP1K-RIP3K complex formation. | 29102662 |
| 2018-02-24 11:33:00 | RIPK1/RIPK3/MLKL-mediated necroptosis may play an important role in nucleus pulposus (NP) cell death induced by continuous mechanical stress. Treatment strategies which aim to regulate necroptosis may prove beneficial, by both reducing NP cells death and slowing IVD degeneration. | 28289909 |
| 2018-02-10 11:09:00 | Shikonin induces glioma cell necroptosis in vitro by reactive oxygen species overproduction and promoting RIP1/RIP3 necrosome formation. | 28816233 |
| 2018-01-13 13:38:00 | This is demonstrated that mild-induced hypothermia treatment significantly reduced RIPK-1 upregulation, which may inhibit necroptosis and apoptosis pathways after moderate traumatic brain injury. | 28140659 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
D3ZYL0_RAT
UniprotKB:
D3ZYL0
UniParc:
UPI000017EF0C
EMBL:
AABR07027441,
CH473977
Ensembl:
ENSRNOG00000017787
KO:
rno:306886
|
| Nucleutide sequences |
EMBL-CDS:
EDL98323.1
Gene_ORFName:
rCG_43941
Ensembl_TRS:
ENSRNOT00000023962
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000023962
RefSeq:
XP_017456016.1,
XP_017456017.1,
XP_017456018.1,
XP_017456013.1,
NP_001100820.1,
XP_017456012.1,
XP_017456014.1,
XP_017456015.1
|
| Others |
UniRef100:
UniRef100_D3ZYL0
UniRef90:
UniRef90_D3ZYL0
UniRef50:
UniRef50_Q60855
UniGene:
Rn.7572
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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