| Type | Description |
|---|---|
| Definition | eph receptor B4a |
| Date | Results | Publications |
|---|---|---|
| 2019-03-16 10:13:00 | Immunoblot analysis using zebrafish lysates demonstrated over-activation of mTORC1 as a consequence of reduced EPHB4 signaling. Strikingly, drugs that inhibit mTOR signaling or RAS-MAPK signaling effectively rescued the misbranching phenotype in a comparable manner. | 29905864 |
| 2015-05-23 11:38:00 | EphrinB ligands B2a and B3b, the Ephb4a receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton. | 25725065 |
| 2014-08-23 10:37:00 | overexpression of mTORC1 in endothelial cells exacerbated vascular phenotypes in animals with reduced EPHB4 or RASA1, suggesting a functional EPHB4/RASA1/mTORC1 signaling axis in endothelial cells | 24837431 |
| 2010-01-21 00:00:00 | first embryonic vein formed by selective sprouting of progenitor cells from precursor vessel, followed by vessel segregation; these processes were regulated by EphrinB2 & EphB4 which are expressed in arterial-fated & venous-fated progenitors respectively | 19815777 |
| Type | IDs |
|---|---|
| Synonymous | cb646, ephB4, rtk5 |
| Gene |
UniProtKB-ID:
EPB4A_DANRE
UniprotKB:
O73875
UniParc:
UPI0001E92824
EMBL:
CABZ01112153,
CU928075,
FO904976,
CABZ01112154,
CABZ01112157,
CABZ01112155,
CABZ01093042,
AJ005026,
CU682352,
CABZ01112156,
CABZ01093043
Ensembl:
ENSDARG00000100725
KO:
dre:30688
|
| Nucleutide sequences |
EMBL-CDS:
CAA06299.2
Ensembl_TRS:
ENSDART00000187955
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000152897
RefSeq:
NP_571489.1,
XP_021331676.1
|
| Others |
UniRef100:
UniRef100_O73875
UniRef90:
UniRef90_O73875
UniRef50:
UniRef50_O73875
UniGene:
Dr.5764
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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