| Type | Description |
|---|---|
| Definition | holocytochrome c synthase |
| Date | Results | Publications |
|---|---|---|
| 2017-07-29 10:51:00 | Data suggest that although HCCS mediates heme attachment to N-terminal cysteine in heme-attachment site (CXXXH) of cytochrome C variants, up to 50% of cytochrome C produced is modified in an oxygen-dependent manner, resulting in a mixed population of cytochrome c. [HCCS = holocytochrome c synthase] | 28617588 |
| 2017-05-13 13:43:00 | Bacterial cyt c biogenesis pathways (Systems I and II) appear to recognize simply the CXXCH motif, not requiring alpha helix-1. Results here explain mechanistically how HCCS (System III) requires an extended region adjacent to CXXCH for maturation. | 27387500 |
| 2014-12-27 13:59:00 | cysteines and histidine of the heme attachment site, Cys-XX-Cys-His play a key role in mitochondrial holocytochrome c synthase | 25170082 |
| 2014-10-18 12:28:00 | These data indicate that heme contacts mediated by residues within these domains modulate the dynamics of heme binding and contribute to the stability of the HCCS-heme-cytochrome c steady state ternary complex. | 25054239 |
| 2013-09-07 10:44:00 | Identification of a deletion in two patients, including HCCS, leads to the diagnosis of microphthalmia with linear skin defects syndrome | 23401659 |
| Type | IDs |
|---|---|
| Synonymous | CCHL, LSDMCA1, MCOPS7, MLS |
| Gene |
UniProtKB-ID:
CCHL_HUMAN,
A0A024RBY9_HUMAN
UniprotKB:
P53701,
A0A024RBY9
UniParc:
UPI00001272B7
EMBL:
BC095455,
AF053015,
AF053011,
AF053014,
AK097815,
AF053013,
U36787,
AF053012,
BC001691,
CH471074,
AF053010
Ensembl:
ENSG00000004961
KO:
hsa:3052
|
| Nucleutide sequences |
EMBL-CDS:
AAC35274.1,
AAH01691.1,
BAG53533.1,
AAB19007.1,
AAH95455.1,
EAW98783.1,
EAW98785.1,
EAW98784.1
Gene_ORFName:
hCG_401192
Ensembl_TRS:
ENST00000380762,
ENST00000380763,
ENST00000321143
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000370140,
ENSP00000326579,
ENSP00000370139
RefSeq:
NP_005324.3,
NP_001116080.1,
XP_024308136.1,
NP_001165462.1
|
| Others |
UniRef100:
UniRef100_P53701
UniRef90:
UniRef90_P53701
UniRef50:
UniRef50_P53701
UniGene:
Hs.211571
CCDS:
CCDS14139.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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