| Type | Description |
|---|---|
| Definition | survival of motor neuron 1, telomeric |
| Date | Results | Publications |
|---|---|---|
| 2018-05-05 10:45:00 | we established that the additional supply of Smn protein in motoneurons is necessary for proper axonogenesis in a cell-autonomous manner | 27273160 |
| 2017-12-09 11:15:00 | In motor neurons, smn1 interacts with the RNA binding protein, HuD and regulates motoneuron development and function. | 29061699 |
| 2017-06-03 11:28:00 | our finding that elevation of Pgk1 levels or activity, via injection of Pgk1 mRNA or treatment with terazosin respectively, robustly ameliorated MN pathology in smn morphant zebrafish provides an initial demonstration that these pathways are amenable to therapeutic intervention. | 28426667 |
| 2017-01-11 17:05:00 | Reduction of Gemin2, unlike reduction of SMN, in zebrafish embryos does not directly cause motor axon outgrowth defects. | 18000835 |
| 2014-11-29 12:24:00 | SMN deficiency affects splicing and abundance of nrxn2a. This may explain the pre-synaptic defects at neuromuscular endplates in SMA pathophysiology. | 24218366 |
| Type | IDs |
|---|---|
| Synonymous | fa12d01, smn, wu:fa12d01 |
| Gene |
UniProtKB-ID:
SMN1_DANRE
UniprotKB:
Q9W6S8
UniParc:
UPI0000135AB3
EMBL:
Y17256
Ensembl:
ENSDARG00000018494
KO:
dre:30432
|
| Nucleutide sequences |
EMBL-CDS:
CAB41938.1
Ensembl_TRS:
ENSDART00000028099
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000017636
RefSeq:
NP_571266.1
|
| Others |
UniRef100:
UniRef100_Q9W6S8
UniRef90:
UniRef90_Q9W6S8
UniRef50:
UniRef50_Q9W6S8
UniGene:
Dr.75206
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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