| Type | Description |
|---|---|
| Definition | smoothened, frizzled class receptor |
| Date | Results | Publications |
|---|---|---|
| 2016-01-16 10:28:00 | Our study implicates PDE4 as a target for Hh inhibition, suggests an improved strategy for Hh-dependent cancer therapy, and identifies a unique probe of downstream-of-Smo Hh modulation. | 25818300 |
| 2015-05-16 12:58:00 | The cysteine-rich SMO domain is required for signaling in response to native Hedgehog ligands, showing that it is an important regulatory module for Smo activation. | 24171105 |
| 2014-05-03 10:36:00 | Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling. | 24504339 |
| 2014-01-18 11:10:00 | Fine coordination of smoothened activity by the miR-30 family allows the correct specification and differentiation of distinct muscle cell types during zebrafish embryonic development. | 23755189 |
| 2010-01-21 00:00:00 | Data suggest that a G protein-coupled receptor kinase, perhaps GRK2 or 3, functions as a vertebrate kinase for Smoothened, promoting Hedgehog signal transduction during early development. | 18815277 |
| Type | IDs |
|---|---|
| Synonymous | CHUNP6862, smoh, smu, wu:fb70b01, wu:fc39h03 |
| Gene |
UniProtKB-ID:
Q5RH73_DANRE
UniprotKB:
Q5RH73
UniParc:
UPI000019D96F
EMBL:
BX571796
Ensembl:
ENSDARG00000002952
KO:
dre:30225
|
| Nucleutide sequences |
Ensembl_TRS:
ENSDART00000005985
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000013486
RefSeq:
NP_571102.2
|
| Others |
UniRef100:
UniRef100_Q5RH73
UniRef90:
UniRef90_Q90X26
UniRef50:
UniRef50_Q90X26
UniGene:
Dr.114683
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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