| Type | Description |
|---|---|
| Definition | presenilin 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:11:00 | brains from zebrafish heterozygous for a single, early onset of familial Alzheimer's disease-like mutation in their PSEN1-orthologous gene, psen1, were analyzed. | 31053140 |
| 2018-08-11 11:27:00 | Presenilin-1 targeted morpholino induces cognitive deficits, increased brain Abeta1-42 and decreased synaptic marker PSD-95 | 28623607 |
| 2017-02-18 12:02:00 | Using an antisense morpholino oligonucleotide, study blocked induction of PS1IV isoform that normally occurs under hypoxia,identified gene regulatory networks that are modulated by PS1IV: observed changes in expression of genes controlling inflammation, vascular development, the UPR, protein synthesis, calcium homeostasis, catecholamine biosynthesis, TOR signaling, and cell proliferation | 27031468 |
| 2016-04-30 10:55:00 | Both human PS2V and zebrafish PS1IV can stimulate gamma-secretase activity despite extreme structural divergence. | 25814654 |
| 2013-03-23 11:54:00 | We identified psen1 as a regulator of the development of histaminergic neurons in zebrafish | 23345232 |
| Type | IDs |
|---|---|
| Synonymous | pre1, psen, zf-PS1, zfPS1 |
| Gene |
UniProtKB-ID:
PSN1_DANRE,
F8W381_DANRE,
F1Q8Y6_DANRE
UniprotKB:
Q9W6T7,
F8W381,
F1Q8Y6
UniParc:
UPI00000FBD3D,
UPI0002151529,
UPI000056A67D
EMBL:
AJ132931,
CU634006,
BC054639,
CU694267
Ensembl:
ENSDARG00000004870
KO:
dre:30221
|
| Nucleutide sequences |
EMBL-CDS:
CAB40386.1,
AAH54639.1
Ensembl_TRS:
ENSDART00000149864,
ENSDART00000166687,
ENSDART00000185749
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000124467,
ENSDARP00000146226,
ENSDARP00000136264
RefSeq:
XP_005169939.1,
XP_005169940.1,
NP_571099.1
|
| Others |
UniRef100:
UniRef100_F1Q8Y6,
UniRef100_Q9W6T7,
UniRef100_F8W381
UniRef90:
UniRef90_Q9W6T7
UniRef50:
UniRef50_Q9W6T7
UniGene:
Dr.75852
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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