| Type | Description |
|---|---|
| Definition | patched 2 |
| Date | Results | Publications |
|---|---|---|
| 2013-02-16 10:26:00 | We have identified 18 recessive mutations affecting development of the zebrafish visual system and we have characterized a novel splice-acceptor site mutation in patched2 that results in enhanced Hh pathway activity and colobomas. | 23150614 |
| 2012-01-14 10:45:00 | Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2-/- mutants. | 22003118 |
| 2011-06-25 15:01:00 | The Hedgehog co-receptors patched1 and patched2 are expressed in regions of the perichondrium that will form bone before the onset of ossification. | 21126582 |
| 2010-01-21 00:00:00 | The generation and characterization of the ptc1;ptc2 double mutant assigned novel and unexpected functions to the Hh signaling pathway. | 18284698 |
| 2010-01-21 00:00:00 | Positional cloning of blowout identified a nonsense mutation in patched1, a negative regulator of the Hedgehog pathway, as the underlying cause of the blowout phenotype. | 18479681 |
| Type | IDs |
|---|---|
| Synonymous | blowout, blw, etlD309849.2, ptc-1, ptc1, ptch1 |
| Gene |
UniProtKB-ID:
F1Q8S0_DANRE
UniprotKB:
F1Q8S0
UniParc:
UPI0001E926C0
EMBL:
BX649493
Ensembl:
ENSDARG00000055026
KO:
dre:30181
|
| Nucleutide sequences |
Ensembl_TRS:
ENSDART00000077304
|
| Protein sequencees |
Ensembl_PRO:
ENSDARP00000071771
RefSeq:
NP_571063.2
|
| Others |
UniRef100:
UniRef100_F1Q8S0
UniRef90:
UniRef90_A0A553QIP9
UniRef50:
UniRef50_Q98864
UniGene:
Dr.75755
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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