| Type | Description |
|---|---|
| Definition | aph-1 homolog B, gamma secretase subunit |
| Date | Results | Publications |
|---|---|---|
| 2014-01-25 10:06:00 | Notch ligand binding leads to gamma-secretase-mediated proteolytic cleavage of the Notch receptor releasing the Notch intracellular domain, resulting in its subsequent translocation into the nucleus and gene expression regulation | 24397211 |
| 2011-07-29 15:27:00 | Pharmacogenetically bred apomorphine-susceptible Wistar rats have only one or two copies of the Aph-1b gene; in these rats, gamma-secretase activity is altered, leading to a complex phenotype. | 16249316 |
| 2010-04-19 11:22:00 | Aph1b and KCnIP1 are significantly differentially expressed in a number of brain tissues of a schizophrenia model; KCnIP1 is an attractive novel candidate gene that may play a role in the complex phenotype | 19896980 |
| 2010-01-21 00:00:00 | low levels of Aph-1b mRNA and gamma-secretase activity observed in the I/I and II/II rats during the entire developmental period may well underlie their complex phenotype | 16718279 |
| Type | IDs |
|---|---|
| Synonymous | APH-1B' |
| Gene |
UniProtKB-ID:
Q0PY50_RAT
UniprotKB:
Q0PY50
UniParc:
UPI00001CA583
EMBL:
AABR07070490,
BC166592,
DQ672552,
AABR07070498,
AABR07070499,
AABR07070491,
AABR07070497,
AABR07070492,
AABR07070494,
AABR07070495,
AABR07070496,
AABR07070493
Ensembl:
ENSRNOG00000027295
KO:
rno:300802,
rno:108348064
|
| Nucleutide sequences |
EMBL-CDS:
AAI66592.1,
ABG66305.1
Ensembl_TRS:
ENSRNOT00000024207,
ENSRNOT00000024176,
ENSRNOT00000057704
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000024176,
ENSRNOP00000054515,
ENSRNOP00000024207
RefSeq:
NP_001040555.1
|
| Others |
UniRef100:
UniRef100_Q0PY50
UniRef90:
UniRef90_Q8C7N7
UniRef50:
UniRef50_Q8C7N7
UniGene:
Rn.103390
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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