| Type | Description |
|---|---|
| Definition | SAM pointed domain containing ets transcription factor |
| Date | Results | Publications |
|---|---|---|
| 2019-04-20 11:11:00 | that Spdef regulates baseline Muc5b expression in respiratory epithelia but does not contribute to Muc5b regulation in a mouse model of Muc5b-predominant mucus obstruction caused by airway dehydration | 29579396 |
| 2018-07-14 12:14:00 | a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF. | 29477409 |
| 2017-09-09 10:12:00 | In studies of mice and human CRC, we found that SPDEF induces a quiescent state in CRC cells by disrupting binding of b-catenin to TCF1 and TCF3 and regulation of genes that control the cell cycle. | 28390865 |
| 2015-08-22 10:47:00 | SPDEF causes goblet cell differentiation and Th2 inflammation during postnatal development and is required for goblet cell metaplasia and normal Th2 inflammatory responses to house dust mite aeroallergen. | 25866971 |
| 2015-07-25 11:38:00 | SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene. | 25254494 |
| Type | IDs |
|---|---|
| Synonymous | PDEF, Pse |
| Gene |
UniProtKB-ID:
SPDEF_MOUSE
UniprotKB:
Q9WTP3
UniParc:
UPI00000222A9
EMBL:
AB019436,
AK078863,
BC012648
Ensembl:
ENSMUSG00000024215
KO:
mmu:30051
|
| Nucleutide sequences |
EMBL-CDS:
BAA77329.1,
BAC37426.1,
AAH12648.1
Ensembl_TRS:
ENSMUST00000167489,
ENSMUST00000025054
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000025054,
ENSMUSP00000127056
RefSeq:
NP_001344657.1,
XP_006524443.1,
NP_038919.1,
XP_006524442.1,
XP_006524444.1
|
| Others |
UniRef100:
UniRef100_Q9WTP3
UniRef90:
UniRef90_Q9WTP3
UniRef50:
UniRef50_O95238-2
UniGene:
Mm.26768
CCDS:
CCDS28568.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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