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300438 Ldlr

300438

Ldlr

low density lipoprotein receptor

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition low density lipoprotein receptor

研究结论

Date Results Publications
2019-06-01 10:41:00 Deficiency of either Ldlr or Apoe genes induced hyperlipidemia, which promoted endothelial inflammation and led to typical atherosclerosis in rats on normal or Western diets. 29459263
2019-04-27 10:55:00 This suggests that overexpression of HNF1alpha gene in liver of lipectomized rats can lead to overproduction of PCSK9. In conclusion, up-regulation of PCSK9, due to overexpression of HNF1alpha gene in liver of lipectomized rats and subsequently increase in circulating PCSK9 concentration lead to decrease in liver LDL-R level. 30483910
2018-10-06 11:56:00 up-regulation of intestinal gene expression of LDL-R and PCSK9 following voluntary wheel running 29938676
2017-10-07 13:02:00 LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs 28108572
2016-09-24 10:55:00 Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol accumulation via increased LDL cholesterol uptake into the liver with resulting persistent increases in hepatic cholesterol accumulation. 27401460

名称对应

Type IDs
Synonymous LDLRA
Gene
UniProtKB-ID: LDLR_RAT
UniprotKB: P35952
UniParc: UPI000012E352
EMBL: X13722
KO: rno:300438
Nucleutide sequences
EMBL-CDS: CAA32001.1
Protein sequencees
RefSeq: NP_786938.2
Others
UniRef100: UniRef100_P35952
UniRef90: UniRef90_P35952
UniRef50: UniRef50_P35951
UniGene: Rn.10483

全选

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研究热度

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