| Type | Description |
|---|---|
| Definition | leucine-rich repeat kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:30:00 | VIP Induces Changes in the F-/G-Actin Ratio of Schlemm's Canal Endothelium via LRRK2 Transcriptional Regulation. | 32572455 |
| 2020-09-19 16:27:00 | Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. | 32631998 |
| 2020-05-23 11:55:00 | Repeated exposure to inflammatory triggers may be needed for LRRK2 mutation carriers to develop active PD. | 30452424 |
| 2020-03-14 11:47:00 | Our work defines a novel interaction between the LRRK2 protein and the vATPase a1 subunit and demonstrates a mode of action by which drugs may rescue lysosomal dysfunction. These results demonstrate the importance of LRRK2 in lysosomal biology, as well as the critical role of the lysosome in PD. | 31039583 |
| 2020-01-11 10:50:00 | Our study demonstrates extensive alterations across the endocytic pathway associated with LRRK2 mutations in iPSC-derived dopaminergic neurons and BAC transgenic rats | 30954703 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
F1LNJ1_RAT
UniprotKB:
F1LNJ1
UniParc:
UPI0000DA2D63
EMBL:
AC112081,
AC108595
Ensembl:
ENSRNOG00000004048
|
| Nucleutide sequences |
Ensembl_TRS:
ENSRNOT00000005438
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000005438
RefSeq:
XP_006242252.1,
NP_001178718.1,
XP_008763911.1
|
| Others |
UniRef100:
UniRef100_F1LNJ1
UniRef90:
UniRef90_F1LNJ1
UniRef50:
UniRef50_Q5S007
UniGene:
Rn.213971
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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