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29986 SLC39A2

29986

SLC39A2

solute carrier family 39 member 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition solute carrier family 39 member 2

研究结论

Date Results Publications
2019-12-14 10:13:00 results provide the first structural evidence for the previously observed pH and voltage modulation of ZIP2-mediated metal transport, identify the substrate-binding site, and suggest a structure-based transport mechanism for the ZIP2 transporter. 30914478
2019-02-09 12:43:00 Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. 29791142
2018-12-22 12:01:00 Results showed decreased expression of Zn uptake transporters ZIP2 and ZIP4 on mRNA and protein level correlating with SHANK3 expression levels, and found reduced levels of ZIP4 protein co-localizing with SHANK3 at the plasma membrane. ZIP4 exists in a complex with SHANK3. Further results confirmed a link between enterocytic SHANK3, ZIP2 and ZIP4. 28345660
2018-08-18 11:42:00 the splice switch to DeltaC-ZIP2 as well as decreased expression of other ZIPs caused zinc deficiency, which is sufficient for induction of MUC5AC. 29289532
2016-10-22 10:30:00 ZIP2 Gln/Arg/Leu polymorphism involve in proinflammatory mediation and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype 26643924

名称对应

Type IDs
Synonymous 6A1, ETI-1, ZIP-2, ZIP2
Gene
UniProtKB-ID: S39A2_HUMAN
UniprotKB: Q9NP94
UniParc: UPI000013E502, UPI00021CEF90
EMBL: AY029483, BC110057, BC098254, BC096723, AL355922, AF186081, AL161668, AK314974, D83039
Ensembl: ENSG00000165794
KO: hsa:29986
Nucleutide sequences
EMBL-CDS: AAI10058.1, AAH96723.1, BAA94313.1, AAF35832.1, AAK40258.1, AAH98254.1, BAG37473.1
Ensembl_TRS: ENST00000298681, ENST00000554422
Protein sequencees
Ensembl_PRO: ENSP00000452568, ENSP00000298681
RefSeq: NP_055394.2, NP_001243517.1
Others
UniRef100: UniRef100_Q9NP94
UniRef90: UniRef90_Q9NP94
UniRef50: UniRef50_Q9NP94
UniGene: Hs.175783
CCDS: CCDS58303.1, CCDS9563.1

全选

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