| Type | Description |
|---|---|
| Definition | nuclear receptor binding factor 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:57:00 | implicates NRBF2 deficiency as a risk factor for cognitive impairment associated with AD, but also support the idea of NRBF2 as a potential therapeutic target for Alzheimer's Disease | 31775806 |
| 2019-07-06 11:19:00 | NRBF2 plays an important role in regulating degradation of APP-C-terminal fragments through modulating autophagy. | 28980867 |
| 2017-12-02 10:39:00 | Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure. | 27385829 |
| 2017-11-26 00:02:00 | This study reveals NRBF2 as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. | 28059666 |
| 2017-11-18 12:45:00 | Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human), were characterized. | 27630019 |
| Type | IDs |
|---|---|
| Synonymous | COPR, COPR1, COPR2, NRBF-2 |
| Gene |
UniProtKB-ID:
NRBF2_HUMAN
UniprotKB:
Q96F24
UniParc:
UPI00017A8158,
UPI0000190901,
UPI000006D398
EMBL:
AK054957,
CH471083,
AL590502,
BC011707,
AY267840,
AK301656,
AF267866,
AL136656,
AY267839
Ensembl:
ENSG00000148572
KO:
hsa:29982
|
| Nucleutide sequences |
EMBL-CDS:
AAP03081.1,
EAW54241.1,
BAG63132.1,
AAG44735.1,
AAH11707.1,
AAP03082.1,
BAB70833.1,
CAB66591.1
Ensembl_TRS:
ENST00000277746,
ENST00000435510
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000397502,
ENSP00000277746
RefSeq:
NP_110386.2,
NP_001269334.1,
XP_006717873.1
|
| Others |
UniRef100:
UniRef100_Q96F24
UniRef90:
UniRef90_Q96F24
UniRef50:
UniRef50_Q96F24
UniGene:
Hs.449628
CCDS:
CCDS60537.1,
CCDS7268.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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